Obesity in relation to lung cancer incidence in African American women.
Obesity in relation to lung cancer incidence in African American women.
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DOI：
10.1007/s10552-013-0245-6
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发表时间：
2013-09
影响因子：
2.3
通讯作者：
Palmer, Julie R.
中科院分区：
文献类型：
--
作者：
Bethea, Traci N.;Rosenberg, Lynn;Charlot, Marjory;O'Connor, George T.;Adams-Campbell, Lucile L.;Palmer, Julie R.
虽然一些研究发现体重指数（BMI）和肺癌风险之间存在负相关，但在非裔美国人中这种关系的信息很少，他们的肺癌发病率较高。我们在黑人女性健康研究中评估了BMI与肺癌发病率的关系，该研究是一项对美国59，000名女性进行的持续前瞻性随访研究。使用考克斯比例风险模型估计不同BMI水平相对于BMI 18.5-24.9 kg/m2（“正常体重”）的风险比，并调整年龄、教育、吸烟包年数和其他协变量。另外两个人体测量指标，腰围（WC）和腰/臀比（WHR）也进行了评估。从1995年到2011年，共发现了323例原发性肺癌病例。BMI ≥30相对于BMI 18.5-24.9的风险比（HR）为0.69（95%置信区间0.51-0.92）。正如预期的那样，吸烟与肺癌风险增加密切相关。在按吸烟状态分层的分析中，当前吸烟者中BMI ≥30相对于BMI 18.5-24.9的HR为0.62（0.38-1.00），既往吸烟者中为0.90（0.56-1.42），从不吸烟者中为0.83（0.41-1.70）（相互作用p = 0.28）。控制吸烟包年数或开始吸烟的年龄对风险比几乎没有影响。WC和WHR与肺癌风险无显著相关性。我们的研究结果表明，高BMI与非洲裔美国妇女患肺癌的风险较低有关，特别是在目前吸烟者中。
Although a number of studies have found an inverse association between body mass index (BMI) and risk of lung cancer, there is little information on this relation in African Americans, who experience a higher incidence of lung cancer. We assessed the relation of BMI to incidence of lung cancer in the Black Women’s Health Study, an ongoing prospective follow-up of 59,000 women in the United States. Cox proportional hazard models were used to estimate hazard ratios for various levels of BMI relative to BMI 18.5–24.9 kg/m2 (“normal weight”) with adjustment for age, education, pack-years of smoking, and other covariates. Two other anthropometric measures, waist circumference (WC) and waist/hip ratio (WHR) were also assessed. A total of 323 primary lung cancer cases were identified from 1995 to 2011. The hazard ratio (HR) for BMI ≥30 relative to BMI 18.5–24.9 was 0.69 (95% confidence interval 0.51–0.92). As expected, cigarette smoking was strongly associated with increased risk of lung cancer. In analyses stratified by smoking status, the HR for BMI ≥30 relative to BMI 18.5–24.9 was 0.62 (0.38–1.00) among current smokers, 0.90 (0.56–1.42) among former smokers, and 0.83 (0.41–1.70) among never smokers (p for interaction= 0.28). Control for pack-years of smoking or age started smoking had little effect on the hazard ratios. WC and WHR were not materially associated with lung cancer risk. Our results indicate that high BMI is associated with a lower risk of lung cancer in African American women, particularly among current smokers.
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DOI：
10.1158/1940-6207.capr-08-0082
发表时间：
2008-09
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Etzel CJ;Kachroo S;Liu M;D'Amelio A;Dong Q;Cote ML;Wenzlaff AS;Hong WK;Greisinger AJ;Schwartz AG;Spitz MR
通讯作者：
Spitz MR
影响因子：
2.3
作者：
Andreotti, Gabriella;Hou, Lifang;Freeman, Laura E. Beane;Mahajan, Rajeev;Koutros, Stella;Coble, Joseph;Lubin, Jay;Blair, Aaron;Hoppin, Jane A.;Alavanja, Michael
通讯作者：
Alavanja, Michael
影响因子：
3.7
作者：
Lin IH;Ho ML;Chen HY;Lee HS;Huang CC;Chu YH;Lin SY;Deng YR;He YH;Lien YH;Hsu CW;Wong RH
通讯作者：
Wong RH
影响因子：
3.8
作者：
Jin Y;Xu H;Zhang C;Kong Y;Hou Y;Xu Y;Xue S
通讯作者：
Xue S
影响因子：
6.9
作者：
Krishnan, Supriya;Rosenberg, Lynn;Palmer, Julie R.
通讯作者：
Palmer, Julie R.