Body mass index, agricultural pesticide use, and cancer incidence in the Agricultural Health Study cohort.
Body mass index, agricultural pesticide use, and cancer incidence in the Agricultural Health Study cohort.
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DOI：
10.1007/s10552-010-9603-9
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发表时间：
2010-11
影响因子：
2.3
通讯作者：
Alavanja, Michael
中科院分区：
文献类型：
--
作者：
Andreotti, Gabriella;Hou, Lifang;Freeman, Laura E. Beane;Mahajan, Rajeev;Koutros, Stella;Coble, Joseph;Lubin, Jay;Blair, Aaron;Hoppin, Jane A.;Alavanja, Michael
肥胖与包括结肠癌、食管下段癌、肾癌、女性乳腺癌和子宫内膜癌在内的多种癌症风险增加有关。一些研究表明，农药与农业人群患癌风险升高有关。肥胖和农药使用对癌症风险的相互作用尚未得到充分研究。利用农业健康研究的数据，我们研究了体重指数（BMI）与17个部位癌症风险之间的关联，以及BMI和农药使用之间的相互作用。1993年至1997年期间，爱荷华州和北卡罗来纳州的农药施药者（主要是农民）及其配偶参与了研究，并随访至2005年。这项分析包括39628名男性和28319名女性，他们提供了农药使用、身高和体重数据信息，且在入组时无癌症。在所有受试者中，64%超重或肥胖，在随访期间诊断出4432例癌症。我们发现男性BMI（连续变量）与结肠癌之间（风险比（HR）为1.05，95%置信区间（CI）为1.02 - 1.09）以及绝经后女性BMI与乳腺癌之间（HR为1.03，95% CI为1.01 - 1.06）存在正相关，在曾经吸烟的男性中BMI与肺癌之间存在负相关（HR为0.92，95% CI为0.88 - 0.96）。曾经使用过呋喃丹（HR = 1.10，95% CI为1.04 - 1.17）、异丙甲草胺（HR = 1.09，95% CI为1.04 - 1.15）和甲草胺（HR = 1.08，95% CI为1.03 - 1.13）的男性，其BMI与结肠癌之间存在显著正相关，但未使用者不存在这种相关性。曾经吸烟并使用过呋喃丹的男性，其BMI与肺癌之间存在正相关，但不显著，而呋喃丹使用者存在显著负相关。这些发现表明某些农药可能改变BMI与结肠癌和肺癌风险之间的关联，应在其他人群中进一步评估。
Obesity is associated with increased risks of several cancers including, colon, lower esophagus, kidney, female breast, and endometrium. Some studies have associated pesticides with higher risks of cancer in agricultural populations. The interaction between obesity and pesticide use on cancer risk has not been well studied. Using data from the Agricultural Health Study we examined the association between body mass index (BMI) and the risk of cancer at 17 sites, and the interaction between BMI and pesticide use. Pesticide applicators (primarly farmers), and their spouses residing in Iowa and North Carolina were enrolled between 1993 and 1997 and followed through 2005. This analysis included 39,628 men and 28,319 women who provided information on pesticide use, height and weight data, and were cancer-free at enrollment. Of all subjects, 64% were overweight or obese, and 4,432 incident cancers were diagnosed during the follow-up period. We found positive associations between BMI (continuous) and colon cancer among men (Hazard Ratio (HR) 1.05, 95% confidence interval (CI) 1.02–1.09) and breast cancer among postmenopausal women (HR 1.03, 95% CI 1.01–1.06), as well as an inverse association with lung cancer among men who were ever smokers (HR 0.92, 95% CI 0.88–0.96). Men who ever used carbofuran (HR=1.10, 95% CI 1.04–1.17), metolachlor (HR=1.09, 95% CI 1.04–1.15), and alachlor (HR=1.08, 95% CI 1.03–1.13) had significant positive associations between BMI and colon cancer, but non-users did not. Men who ever smoked and used carbofuran had a positive, although not significant, association between BMI and lung cancer, while users of carbofuran had a significant inverse association. These findings, which suggest that certain pesticides may modify the association between BMI and colon and lung cancer risk, should be further evaluated in other populations.
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在农业健康研究中，职业暴露于carbofuran和癌症的发病率。
影响因子：
10.4
作者：
通讯作者：
--
影响因子：
8.3
作者：
Kang, Daehee;Park, Sue Kyung;Alavanja, Michael
通讯作者：
Alavanja, Michael
DOI：
10.1038/sj.jea.7500232
发表时间：
2002-09-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Hoppin, JA;Yucel, F;Sandler, DP
通讯作者：
Sandler, DP
影响因子：
5
作者：
Butler, LM;Sinha, R;Sandler, RS
通讯作者：
Sandler, RS
影响因子：
9.6
作者：
Kanashiki, A;Sairenchi, T;Sekizawa, K
通讯作者：
Sekizawa, K