The use of topical minoxidil to accelerate nail growth: a pilot study
The use of topical minoxidil to accelerate nail growth: a pilot study
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使用局部米诺地尔加速指甲生长：一项试点研究
DOI：
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发表时间：
2017
影响因子：
3.6
通讯作者：
Kathleen Nicoletti
中科院分区：
文献类型：
--
作者：
Kumpol Aiempanakit;A. Geater;Preeyachat Limtong;Kathleen Nicoletti
指甲的线性生长速度受各种条件的影响，其中之一是血流量的高低。我们的推测是，局部应用米诺地尔可以增加指甲的生长速度，米诺地尔具有扩张血管的特性。这项研究的目的是确定外用米诺地尔对指甲生长的影响。32名参与者的指甲上涂了5%的米诺地尔溶液，每天两次。随机选择了两组参与者，每组16人。在一组中，应用于右食指和左环指甲，而在另一组中，应用于左指和右环指甲。在每次检查中(第一个月每周一次，第二个月每两周一次)，用数字卡尺测量6个指甲(食指、中指和指环)的长度。从第一周开始，治疗组的平均指甲长度大于未治疗组的平均指甲长度，有统计学意义。没有全身或皮肤副作用。术后1个月，治疗组平均生长4.27 mm/月，对照组为3.91 mm/月(P=0.003)。这些发现表明，5%浓度的米诺地尔局部使用可以刺激指甲生长，从使用的第一周开始就会增加。这一结果可能对指甲疾病的治疗具有重要意义；然而，强烈建议进行一项涉及指甲疾病参与者的可比性研究。
Linear nail growth rate is affected by various conditions, one of which is the level of blood flow. Our supposition was that topical minoxidil, which has vasodilatory properties, can increase the rate of nail growth. The aim of this study was to determine the impact of topical minoxidil on nail growth. A 5% topical minoxidil solution was applied twice daily to the fingernails of 32 participants. Two groups of 16 participants were randomly chosen. In one group, the applications were made to the right index and left ring fingernails, and, in the other, the left index and right ring fingernails. During each visit (weekly during the first month and every 2 weeks during the second month), the nail length of six fingernails (index, middle, and ring of both hands) was measured using a digital caliper. Beginning in the first week, the mean nail length of the treated nails was greater than that of nails in the untreated group with statistical significance. There were no systemic or cutaneous side effects. During the first month, the mean growth of the treated nails was 4.27 mm/month compared with 3.91 mm/month in the untreated nails (P = 0.003). These findings suggest that a 5% concentration of topical minoxidil can stimulate nail growth with increased growth beginning in the first week of application. The results may have important implications for the treatment of nail disorders; however, a comparable study involving participants with nail disorders is highly recommended.
皮肤循环的动态自动调节：无毛皮肤与无毛皮肤的差异控制。
DOI：
10.1152/ajpheart.00622.2004
发表时间：
2005
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Wilson,ThadE;Zhang,Rong;Levine,BenjaminD;Crandall,CraigG
通讯作者：
Crandall,CraigG