Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin.
Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin.
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皮肤循环的动态自动调节：无毛皮肤与无毛皮肤的差异控制。
DOI：
10.1152/ajpheart.00622.2004
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Crandall,CraigG
中科院分区：
文献类型：
--
作者：
Wilson,ThadE;Zhang,Rong;Levine,BenjaminD;Crandall,CraigG
这个项目的目的是验证这样的假设，即无毛和非无毛的皮肤血管系统独立于神经控制，能够自动调节血流。在10名受试者中，对无毛(手掌)和非无毛(前臂)区域的动脉压和皮肤血流量(激光多普勒血流仪)进行了频谱和传递函数分析：基线、节段性注射曲美沙潘和曲美沙潘加振荡下体负压(−5至−10)。振荡的下体负压被用来再生平均动脉压变异性，这种变异性被神经节阻断所消除。通过对Valsalva动作没有心率反应来证实神经节细胞阻滞。在此振荡频率范围内(0.05~0.07赫兹)，计算了血压和皮肤血流量之间的频谱功率和传递函数增益。在此频率范围内，神经节阻滞显著降低前臂和手掌血流的频谱功率，而动脉血压振荡的再生显著增加前臂血流的频谱功率，但不增加手掌血流的频谱功率。振荡下体负压时，血压与皮肤血流量之间的传递函数增益在前臂显著升高(0.28±0.03至0.53±0.02通量单位/mm Hg；P<；0.05)，而在手掌显著降低(4.7±0.5至1.2±0.1通量单位/mm Hg；P<；0.05)。这些数据表明，无毛皮肤独立于神经对血流的控制，具有缓冲血压波动的能力，并显示出一定程度的动态自动调节。相反，这些数据表明非无毛皮肤的动态自我调节能力减弱。
The purpose of this project was to test the hypothesis that, independent of neural control, glabrous and nonglabrous cutaneous vasculature is capable of autoregulating blood flow. In 10 subjects, spectral and transfer function analyses of arterial pressure and skin blood flow (laser-Doppler flowmetry) from glabrous (palm) and nonglabrous (forearm) regions were performed under three conditions: baseline, ganglionic blockade via intravenous trimethaphan administration, and trimethaphan plus oscillatory lower body negative pressure (LBNP; −5 to −10 mmHg) from 0.05 to 0.07 Hz. Oscillatory LBNP was applied to regenerate mean arterial pressure variability that was abolished by ganglionic blockade. Ganglionic blockade was verified by an absence of a heart rate response to a Valsalva maneuver. Spectral power and transfer function gain between blood pressure and skin blood flow were calculated in this oscillatory frequency range (0.05–0.07 Hz). Within this frequency range, ganglionic blockade significantly decreased spectral power of blood flow in both the forearm and palm, whereas regeneration of arterial blood pressure oscillations significantly increased spectral power of forearm blood flow but not palm blood flow. During oscillatory LBNP, transfer function gain between blood pressure and skin blood flow was significantly elevated at the forearm (0.28 ± 0.03 to 0.53 ± 0.02 flux units/mmHg;P< 0.05) but was reduced at the palm (4.7 ± 0.5 to 1.2 ± 0.1 flux units/mmHg;P< 0.05). These data show that independent of neural control of blood flow, glabrous skin has the ability to buffer blood pressure oscillations and demonstrates a degree of dynamic autoregulation. Conversely, these data suggest that nonglabrous skin has diminished dynamic autoregulatory capabilities.
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DOI：
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