To die or not to die: Programmed cell death responses and their interactions with Coxiella burnetii infection.
To die or not to die: Programmed cell death responses and their interactions with Coxiella burnetii infection.
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DOI：
10.1111/mmi.14878
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发表时间：
2022-04
影响因子：
3.6
通讯作者：
Goodman, Alan G.
中科院分区：
文献类型：
--
作者：
Osbron, Chelsea A.;Goodman, Alan G.
伯氏柯克斯体是一种革兰氏阴性、专性胞内、嗜巨噬细胞细菌，是人畜共患病Q热的病原体。Q热的流行病学与受感染动物的存在有关；绵羊、山羊、牛和人类主要通过吸入受污染的气雾剂而感染。在人类中，疾病的急性期主要以流感样症状为特征，大约3%-5%的感染者发展为慢性感染。伯氏梭菌感染可激活多种类型的免疫反应，细菌基因组编码许多与宿主免疫信号机制相互作用的效应蛋白。在这里，我们将讨论两种形式的细胞程序性死亡，细胞凋亡和上睑下垂。细胞凋亡是非炎症性细胞死亡的一种形式，导致小的膜结合小体的吞噬。相反，上睑下垂会导致溶细胞死亡，并伴随着促炎细胞因子的释放。细胞凋亡和上睑下垂都与清除细胞内细菌病原体有关，包括伯氏梭菌。最后，我们将讨论自噬的作用，即不需要的细胞成分在伯氏梭菌感染过程中的降解。综上所述，对这些形式的程序性细胞死亡的审查将开启新的研究问题，旨在对抗这种治疗选择有限的高度传染性病原体。伯氏柯克斯体是一种专性细胞内嗜巨噬细胞细菌，是人畜共患病Q热的病原体。在这篇综述中，我们总结了伯氏梭菌与细胞凋亡、下垂和自噬过程的关系。细菌对这些途径的调节与感染的维持有关，讨论有关宿主-细菌相互作用的已知内容将开启新的研究问题，旨在了解和抗击这种高度传染性的病原体。
Coxiella burnetii is a Gram-negative, obligate intracellular, macrophage-tropic bacterium and the causative agent of the zoonotic disease Q fever. The epidemiology of Q fever is associated with the presence of infected animals; sheep, goats, cattle, and humans primarily become infected by inhalation of contaminated aerosols. In humans, the acute phase of the disease is characterized primarily by influenza-like symptoms, and approximately 3–5% of the infected individuals develop chronic infection. C. burnetii infection activates many types of immune responses, and the bacteria’s genome encodes for numerous effector proteins that interact with host immune signaling mechanisms. Here, we will discuss two forms of programmed cell death, apoptosis and pyroptosis. Apoptosis is a form of non-inflammatory cell death that leads to phagocytosis of small membrane-bound bodies. Conversely, pyroptosis results in lytic cell death accompanied by the release of proinflammatory cytokines. Both apoptosis and pyroptosis have been implicated in the clearance of intracellular bacterial pathogens, including C. burnetii. Finally, we will discuss the role of autophagy, the degradation of unwanted cellular components, during C. burnetii infection. Together, the review of these forms of programmed cell death will open new research questions aimed at combating this highly infectious pathogen for which treatment options are limited. Coxiella burnetii is an obligate intracellular, macrophage-tropic bacterium and the causative agent of the zoonotic disease Q fever. In this review, we summarize the relationships between C. burnetii and the cellular processes of apoptosis, pyroptosis, and autophagy. Bacterial modulation of these pathways has been implicated in the maintenance of infection, and discussion of what is known regarding host-bacterial interactions will open new research questions aimed at understanding and combating this highly infectious pathogen.
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影响因子：
6.7
作者：
Carey KL;Newton HJ;Lührmann A;Roy CR
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
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通讯作者：
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6.7
作者：
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