Population-based comparison of chronic kidney disease prevalence and risk factors among adults living in the Punjab, Northern India and the USA (2013-2015).
Population-based comparison of chronic kidney disease prevalence and risk factors among adults living in the Punjab, Northern India and the USA (2013-2015).
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DOI：
10.1136/bmjopen-2020-040444
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发表时间：
2020-12-13
期刊：
影响因子：
2.9
通讯作者：
Saran R
中科院分区：
文献类型：
--
作者：
Bragg-Gresham J;Thakur JS;Jeet G;Jain S;Pal A;Prasad R;Pennathur S;Saran R
印度的非传染性疾病（NCD）增长令人不安，其中包括慢性肾病（CKD）。最近，世卫组织在印度旁遮普邦开展了一项 STEPS 调查，收集成年人口中非传染性疾病危险因素的数据。我们试图比较印度北部这个大邦和美国之间 CKD 的患病率及其危险因素。样本是从印度旁遮普邦和美国这两个地点抽取的，采用多阶段分层抽样设计来收集代表一般人群的数据。对旁遮普调查 (2014-2015) 的 2002 名参与者和美国 5057 名年龄在 18-69 岁之间的参与者（国家健康和营养检查调查 (NHANES; 2013-2014)）的数据进行了检查。采用修正泊松回归来比较两个样本中 CKD 标记物及其危险因素的患病率。所有分析均使用抽样权重。旁遮普样本的平均年龄显着低于美国（38.3 岁 vs 42.5 岁，p<0.0001）。虽然美国吸烟和肥胖率较高，但旁遮普邦的高血压更为常见（48.2% vs 33.4%，p<0.0001），CKD 患病率存在显着差异，eGFR <60mL/min/1.73m2 的患病率较低（2.0%）。与 3.8%，p<0.0001）相比，旁遮普邦的蛋白尿患病率明显更高（46.7% 与 8.9%，p<0.0001）。这些差异无法用糖尿病和高血压等传统危险因素来解释。我们报告，与美国相比，印度旁遮普邦的蛋白尿患病率惊人地高。这需要进一步研究，并可能对未来进展性 CKD 的负担产生巨大的公共卫生影响。资金来自印度旁遮普邦国家卫生使命、JST 和美国佐治亚州亚特兰大疾病控制和预防中心。
India is witnessing a disturbing growth in non-communicable diseases (NCDs), including chronic kidney disease (CKD). Recently, a WHO STEPS survey was conducted in the state of Punjab, India to collect data from the adult population on NCD risk factors. We sought to compare the prevalence of CKD and its risk factors between this large state in northern India and the USA. Samples were drawn from both locations, Punjab, India and the USA, using multistage stratified sampling designs to collect data representative of the general population. Data from 2002 participants in the Punjab survey (2014–2015) and 5057 in the USA (National Health and Nutrition Examination Survey (NHANES; 2013–2014), between the ages of 18–69 years were examined. Modified Poisson regression was employed to compare prevalence between the two samples for markers of CKD and its risk factors. All analyses used sampling weights. The average age in the Punjab sample was significantly lower than the USA (38.3 vs 42.5 years, p<0.0001). While smoking and obesity were higher in the USA, hypertension was much more common in Punjab (48.2% vs 33.4%, p<0.0001). Significant differences were seen in the prevalence of CKD, with lower prevalence of eGFR <60 mL/min/1.73 m2 (2.0% vs 3.8%, p<0.0001), but markedly higher prevalence of albuminuria (46.7% vs 8.9%, p<0.0001) in Punjab. These differences could not be explained by traditional risk factors such as diabetes and hypertension. We report a strikingly high prevalence of albuminuria in Punjab, India, compared with the USA. This requires further study and may have enormous public health implications for future burden of progressive CKD, end-stage kidney disease, morbidity, mortality and specifically for elevated risk or presence of cardiovascular disease in the northern state of Punjab, India. Funding came from the National Health Mission, Punjab, India, JST and the Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
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影响因子：
1.3
作者：
Kim HJ;Min JY;Seo YS;Min KB
通讯作者：
Min KB
影响因子：
19.6
作者：
Kher, V;Singhal, M
通讯作者：
Singhal, M
影响因子：
5.5
作者：
Levin, Adeera;Stevens, Paul E.
通讯作者：
Stevens, Paul E.
影响因子：
2.7
作者：
Lim, Sangeun;Yu, Hui-Jin;Woo, Hee-Yeon
通讯作者：
Woo, Hee-Yeon
DOI：
10.12659/msm.903660
发表时间：
2017-09-15
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Huang MJ;Wei RB;Zhao J;Su TY;Li QP;Yang X;Chen XM
通讯作者：
Chen XM