Elevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement.
Elevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement.
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DOI：
10.1177/0363546513499308
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发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Mendias CL
中科院分区：
文献类型：
--
作者：
Bedi A;Lynch EB;Sibilsky Enselman ER;Davis ME;Dewolf PD;Makki TA;Kelly BT;Larson CM;Henning PT;Mendias CL
股骨髋臼撞击（FAI）现在是非发育不良髋关节早期软骨和盂唇损伤的最常见原因之一。软骨退化和炎症的生物标志物与骨关节炎有关。目前尚不清楚 FAI 患者的软骨退化和炎症生物标志物水平是否升高。我们假设，与没有 FAI 的运动员相比，患有 FAI 的运动员的炎症 C 反应蛋白 (CRP) 和软骨降解标记物软骨寡聚基质蛋白 (COMP) 的水平会升高。描述性实验室研究方法：将影像学证实 FAI 的男性运动员 (N = 10) 与影像学检查髋部正常、无 FAI 或髋关节发育不良证据的男性运动员 (N = 19) 进行比较。测量了 COMP 和 CRP 的血浆水平，受试者还完成了 Short Form-12 (SF-12) 以及髋关节残疾和骨关节炎结果评分 (HOOS) 调查。与对照运动员相比，患有 FAI 的运动员的 COMP 水平增加了 24%，CRP 水平增加了 276%，SF-12 身体成分分数降低了 22%，所有 HOOS 子量表分数均下降。患有 FAI 的运动员表现出软骨更新增加和全身炎症的早期生化迹象。使用生物标志物可以可靠地检测 FAI 重复性微创伤继发的软骨损伤。将来，这些生物标志物可能会被用作筛查工具，以识别高危患者并评估治疗干预措施（例如髋关节保留手术）在改变骨关节炎自然史和进展方面的功效。
Femoroacetabular impingement (FAI) now represents one of the most common causes of early cartilage and labral damage in the non-dysplastic hip. Biomarkers of cartilage degradation and inflammation are associated with osteoarthritis. It was not known whether patients with FAI have elevated levels of biomarkers of cartilage degradation and inflammation. We hypothesized that, compared to athletes without FAI, athletes with FAI would have elevated levels of the inflammatory C-reactive protein (CRP) and the cartilage degradation marker, cartilage oligomeric matrix protein (COMP). Descriptive laboratory study Methods: Male athletes with radiographically confirmed FAI (N=10) were compared to male athletes with radiographically normal hips with no evidence of FAI or hip dysplasia (N=19). Plasma levels of COMP and CRP were measured, and subjects also completed the Short Form-12 (SF-12) and Hip disability and Osteoarthritis Outcome Score (HOOS) surveys. Compared with control athletes, athletes with FAI had a 24% increase in COMP levels and a 276% increase in CRP levels, as well as a 22% decrease in SF-12 physical component scores, and decreases in all of the HOOS subscale scores. Athletes with FAI demonstrate early biochemical signs of increase cartilage turnover and systemic inflammation. Chondral injury secondary to the repetitive microtrauma of FAI might be reliably detected using biomarkers. In the future, these biomarkers might be utilized as screening tools to identify at-risk patients and assess the efficacy of therapeutic interventions such as hip preservation surgery in altering the natural history and progression to osteoarthritis.
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影响因子：
4.2
作者：
Brand, Richard A.
通讯作者：
Brand, Richard A.
影响因子：
3.7
作者：
Lehmann, Trude G.;Engesaeter, Ingvild O.;Engesaeter, Lars B.
通讯作者：
Engesaeter, Lars B.
影响因子：
2.8
作者：
Haffner, SM
通讯作者：
Haffner, SM
DOI：
10.1097/01.blo.0000096804.78689.c2
发表时间：
2003-12-01
影响因子：
4.2
作者：
Ganz, R;Parvizi, J;Siebenrock, KA
通讯作者：
Siebenrock, KA
影响因子：
24
作者：
Greenland, Philip;Alpert, Joseph S.;Whitman, Gayle R.
通讯作者：
Whitman, Gayle R.