Chronic wasting disease agents in nonhuman primates.

Chronic wasting disease agents in nonhuman primates.
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DOI:
10.3201/eid2005.130778
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发表时间:
2014-05
影响因子:
11.8
通讯作者:
Chesebro B
Chesebro B
中科院分区:
医学2区
文献类型:
--
作者:
Race B;Meade-White KD;Phillips K;Striebel J;Race R;Chesebro B

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慢性消耗病是一种鹿的朊病毒病。评估其人畜共患病潜力至关重要。为了评估灵长类动物的易感性,我们测试了来自2个属的猴子。我们发现,100%的脑内接种和92%的口服接种的松鼠猴是敏感的,但食蟹猴不是,这表明人类可能的风险较低。
Chronic wasting disease is a prion disease of cervids. Assessment of its zoonotic potential is critical. To evaluate primate susceptibility, we tested monkeys from 2 genera. We found that 100% of intracerebrally inoculated and 92% of orally inoculated squirrel monkeys were susceptible, but cynomolgus macaques were not, suggesting possible low risk for humans.
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