Asian ethnicity and breast cancer subtypes: a study from the California Cancer Registry.
Asian ethnicity and breast cancer subtypes: a study from the California Cancer Registry.
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DOI：
10.1007/s10549-010-1173-8
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发表时间：
2011-06
影响因子：
3.8
通讯作者：
Gomez, Scarlett L.
中科院分区：
文献类型：
--
作者：
Telli, Melinda L.;Chang, Ellen T.;Kurian, Allison W.;Keegan, Theresa H. M.;McClure, Laura A.;Lichtensztajn, Daphne;Ford, James M.;Gomez, Scarlett L.
关键词：
乳腺癌分子亚型的分布已被证明因人种/种族而异，突出了宿主因素在乳腺肿瘤生物学中的重要性。我们进行了目前的分析，以确定在加州六个亚裔群体中乳腺癌亚型的人群分布。我们将2002年至2007年期间在加州癌症登记处诊断为偶发性、原发性、浸润性乳腺癌的中国、日本、菲律宾、韩国、越南和南亚患者中每种乳腺癌亚型的免疫组织化学（IHC）替代物定义为：激素受体阳性（HR+）/HER 2-[雌激素受体阳性（ER+）和/或孕酮受体阳性（PR+），人表皮生长因子受体2阴性（HER 2-）]、三阴性（ER-、PR-和HER 2-）和HER 2阳性（ER±、PR±和HER 2+）。我们计算了亚洲族群中乳腺癌亚型的频率，并评估了其与临床和人口统计学因素的相关性。完整的IHC数据可用于8，140名亚洲女性。与非西班牙裔白色女性相比，韩国人[比值比（OR）= 1.8，95%置信区间（CI）= 1.5-2.2]、菲律宾人（OR = 1.3，95% CI = 1.2-1.5），越南人（OR = 1.3，95%CI = 1.1-1.6），中国人（OR =1.1，95%CI = 1.0-1.3）在调整年龄、分期、等级、社会经济地位、组织学、诊断年份、出生地和医院所有权状态。我们报告了一个以亚裔美国人为基础的大型人群队列中HER 2阳性乳腺癌的显著种族差异。鉴于HER 2阳性乳腺癌的预后差和治疗费用高，我们的研究结果对医疗资源利用，癌症生物学和临床护理具有重要意义。
The distribution of breast cancer molecular subtypes has been shown to vary by race/ethnicity, highlighting the importance of host factors in breast tumor biology. We undertook the current analysis to determine population-based distributions of breast cancer subtypes among six ethnic Asian groups in California. We defined immunohistochemical (IHC) surrogates for each breast cancer subtype among Chinese, Japanese, Filipina, Korean, Vietnamese, and South Asian patients diagnosed with incident, primary, invasive breast cancer between 2002 and 2007 in the California Cancer Registry as: hormone receptor-positive (HR+)/HER2− [estrogen receptor-positive (ER+) and/or progesterone receptor-positive (PR+), human epidermal growth factor receptor 2-negative (HER2−)], triple-negative (ER−, PR−, and HER2−), and HER2-positive (ER±, PR±, and HER2+). We calculated frequencies of breast cancer subtypes among Asian ethnic groups and evaluated their associations with clinical and demographic factors. Complete IHC data were available for 8,140 Asian women. Compared to non-Hispanic White women, Korean [odds ratio (OR) = 1.8, 95% confidence interval (CI) = 1.5–2.2], Filipina (OR = 1.3, 95% CI = 1.2–1.5), Vietnamese (OR = 1.3, 95% CI = 1.1–1.6), and Chinese (OR =1.1, 95% CI = 1.0–1.3) women had a significantly increased risk of being diagnosed with HER2-positive breast cancer subtypes after adjusting for age, stage, grade, socioeconomic status, histology, diagnosis year, nativity, and hospital ownership status. We report a significant ethnic disparity in HER2-positive breast cancer in a large population-based cohort enriched for Asian-Americans. Given the poor prognosis and high treatment costs of HER2-positive breast cancer, our results have implications for healthcare resource utilization, cancer biology, and clinical care.
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影响因子：
45.3
作者：
Kurian, Allison W.;Newton Thompson, Rebecca;Garber, Alan M.
通讯作者：
Garber, Alan M.
影响因子：
2.1
作者：
Parise, Carol A.;Bauer, Katrina R.;Caggiano, Vincent
通讯作者：
Caggiano, Vincent
影响因子：
2.3
作者：
Miller, Barry A.;Chu, Kenneth C.;Hankey, Benjamin F.;Ries, Lynn A. G.
通讯作者：
Ries, Lynn A. G.
影响因子：
12.7
作者：
Gomez, SL;Le, GM;O'Connor, L
通讯作者：
O'Connor, L
影响因子：
5
作者：
BLOCK, G;MATANOSKI, GM;SELTSER, RS
通讯作者：
SELTSER, RS