Low-level environmental lead exposure and children's intellectual function: an international pooled analysis.
Low-level environmental lead exposure and children's intellectual function: an international pooled analysis.
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低水平的环境铅暴露和儿童的智力功能：国际合并分析。
DOI：
10.1289/ehp.7688
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发表时间：
2005-07
影响因子：
10.4
通讯作者：
Roberts R
中科院分区：
文献类型：
--
作者：
Lanphear BP;Hornung R;Khoury J;Yolton K;Baghurst P;Bellinger DC;Canfield RL;Dietrich KN;Bornschein R;Greene T;Rothenberg SJ;Needleman HL;Schnaas L;Wasserman G;Graziano J;Roberts R
铅是一种被证实的神经毒素，但关于血铅水平&10μg/dL的铅相关智力缺陷，以及对于给定的暴露变化，较低的暴露是否与更大的缺陷相关，仍存在疑问。这项研究的目的是研究智力测试分数和血铅浓度之间的关系，特别是对于血铅水平最高的儿童&10μg/dL。我们检查了从1,333名儿童收集的数据，这些儿童参与了7项基于人口的国际纵向队列研究，跟踪调查了从出生或婴儿到5-10岁的情况。全量智商得分是主要的结果衡量标准。儿童血铅几何均值峰值为17.8μg/dL，5~7岁降至9.4μg/dL，最大血铅浓度<10μg/dL 2 44例(18%)，最大血铅<7.5μg/dL 10 3例(8%)。调整协变量后，我们发现血铅浓度与智商得分呈负相关。使用对数线性模型，我们发现随着并发血铅水平从2.4g/dL增加到30μg/dL，智商降低6.9点[95%可信区间(CI)4.2-9.4]。血铅从2.4~10μg/dL、10~2 0μg/dL和2 0~30μg/dL升高，估计的智商下降分别为3.9(95%可信区间，2.4~5.3)、1.9(95%可信区间，1.2~2.6)和1.1(95%可信区间，0.7~1.5)。对于给定的血铅增加，最大血铅水平为7.5μg/dL的儿童的铅相关智力下降显著大于≥最大血铅水平为7.5μg/dL的儿童(p=0.015)。我们得出结论，血铅水平最高为7.5μg/dL的儿童在环境中暴露于铅与智力缺陷有关。
Lead is a confirmed neurotoxin, but questions remain about lead-associated intellectual deficits at blood lead levels < 10 μg/dL and whether lower exposures are, for a given change in exposure, associated with greater deficits. The objective of this study was to examine the association of intelligence test scores and blood lead concentration, especially for children who had maximal measured blood lead levels < 10 μg/dL. We examined data collected from 1,333 children who participated in seven international population-based longitudinal cohort studies, followed from birth or infancy until 5–10 years of age. The full-scale IQ score was the primary outcome measure. The geometric mean blood lead concentration of the children peaked at 17.8 μg/dL and declined to 9.4 μg/dL by 5–7 years of age; 244 (18%) children had a maximal blood lead concentration < 10 μg/dL, and 103 (8%) had a maximal blood lead concentration < 7.5 μg/dL. After adjustment for covariates, we found an inverse relationship between blood lead concentration and IQ score. Using a log-linear model, we found a 6.9 IQ point decrement [95% confidence interval (CI), 4.2–9.4] associated with an increase in concurrent blood lead levels from 2.4 to 30 μg/dL. The estimated IQ point decrements associated with an increase in blood lead from 2.4 to 10 μg/dL, 10 to 20 μg/dL, and 20 to 30 μg/dL were 3.9 (95% CI, 2.4–5.3), 1.9 (95% CI, 1.2–2.6), and 1.1 (95% CI, 0.7–1.5), respectively. For a given increase in blood lead, the lead-associated intellectual decrement for children with a maximal blood lead level < 7.5 μg/dL was significantly greater than that observed for those with a maximal blood lead level ≥7.5 μg/dL (p = 0.015). We conclude that environmental lead exposure in children who have maximal blood lead levels < 7.5 μg/dL is associated with intellectual deficits.
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影响因子：
158.5
作者：
BAGHURST, PA;MCMICHAEL, AJ;TONG, SL
通讯作者：
TONG, SL
影响因子：
56.9
作者：
Lanphear, BP
通讯作者：
Lanphear, BP
影响因子：
158.5
作者：
Canfield, RL;Henderson, CR;Lanphear, BP
通讯作者：
Lanphear, BP
影响因子：
120.7
作者：
Moss, ME;Lanphear, BP;Auinger, P
通讯作者：
Auinger, P
影响因子：
158.5
作者：
BELLINGER, D;LEVITON, A;RABINOWITZ, M
通讯作者：
RABINOWITZ, M