Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Han population

Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Han population
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吸烟改变NPPA的两个独立SNP rs5063和rs198358对中国汉族人群中心性肥胖的影响

DOI:
10.1007/s12041-018-0992-y
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发表时间:
2018-09
期刊:
J Genet
影响因子:
--
通讯作者:
Yonghong Zhang
Yonghong Zhang
中科院分区:
其他
文献类型:
--
作者:
Huan Zhang;Xingbo Mo;Zhengyuan Zhou;Zhengbao Zhu;Xingfeng HuangFu;Tan Xu;Aili Wang;Zhirong Guo;Yonghong Zhang

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肥胖是中等收入和高收入国家的第三大死亡风险因素。在中国汉族人群中,CORIN和NPPA基因的DNA多态性是否与肥胖相关,以及这些相关性是否可以通过吸烟来改变尚不清楚,因此招募了一组1507名参与者,并对CORIN和NPPA基因的12个标签单核苷酸多态性(SNP)进行基因分型。回归模型被用来测试SNPs与肥胖的关联。在回归模型中检测到潜在的SNP-吸烟相互作用。NPPA SNPs rs 5063和rs 198358与体重指数(BMI)相关(分别为P = 0.0053和0.0037)。在单变量和多变量校正分析中,Rs 198358与肥胖相关(分别为P = 0.0138和0.0173)。在单变量和多变量校正分析中,Rs 5063与中心性肥胖相关(分别为P = 0.0454和0.0361)。检测到吸烟与rs 5063和rs 198358之间的显著相互作用(分别为P = 0.0019和0.0006)。在亚组分析中,rs 5063和rs 198358与吸烟者的中心性肥胖相关(分别为P = 0.0081和0.0037)。本研究结果表明,吸烟可能会改变中国汉族人群中NPPA SNPs rs 5063和rs 198358对向心性肥胖的影响。需要进一步的研究来证实这种关联并阐明潜在的机制。
Obesity is the third most risk factors of death in the middle-income and high-income countries. Whether DNA polymorphisms in CORIN and NPPA genes were associated with obesity, and if these associations could be modified by smoking in the Chinese Han population were unknown, hence a group of 1507 participants were recruited and genotyped for 12 tag single-nucleotide polymorphisms (SNPs) of CORIN and NPPA genes. Regression models were used to test the associations of SNPs with obesity. The potential SNP–smoking interactions were detected in regression models. NPPA SNPs rs5063 and rs198358 were associated with the body mass index (BMI) ($$P=0.0053$$P=0.0053 and 0.0037, respectively). Rs198358 was associated with obesity in both univariate- and multivariable-adjusted analyses ($$P=0.0138$$P=0.0138 and 0.0173, respectively). Rs5063 was associated with central obesity in both univariate- and multivariable-adjusted analyses ($$P=0.0454$$P=0.0454 and 0.0361, respectively). Significant interactions between cigarette smoking and rs5063 and rs198358 were detected ($$P=0.0019$$P=0.0019 and 0.0006, respectively). In subgroup analyses, rs5063 and rs198358 were associated with central obesity in smokers ($$P=0.0081$$P=0.0081 and 0.0037, respectively). The results of our study demonstrated that the effect of NPPA SNPs rs5063 and rs198358 on central obesity might be modified by smoking in the Chinese Han population. Further studies are needed to confirm the associations and elucidate the underlying mechanisms.
DOI: 10.1074/jbc.274.21.14926
发表时间: 1999-05-21
影响因子: 4.8
作者:
Yan, W;Sheng, N;Wu, QY
通讯作者: Wu, QY
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发表时间: 2015-02-12
期刊: NATURE
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