Finding Solutions for Fibrosis: Understanding the Innate Mechanisms Used by Super-Regenerator Vertebrates to Combat Scarring.
Finding Solutions for Fibrosis: Understanding the Innate Mechanisms Used by Super-Regenerator Vertebrates to Combat Scarring.
复制标题
DOI：
10.1002/advs.202100407
复制
发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Whited JL
中科院分区：
文献类型：
--
作者：
Durant F;Whited JL
软组织纤维化和皮肤瘢痕每年给数百万患者带来巨大的临床负担，目前可用的治疗选择相当有限。尽管我们对哺乳动物的纤维化过程知之甚少，但对抗纤维化和瘢痕形成的新方法是必要的。据推测，疤痕已经进化为一种解决方案，以最大限度地提高愈合速度，减少液体流失和感染。然而，再生动物具有最显著的愈合能力，能够无疤痕愈合，这使得这一假设变得复杂。本综述探讨了通常导致纤维化的成年哺乳动物愈合与无疤痕愈合的再生动物愈合之间观察到的差异。从许多再生和纤维化愈合者的角度深入调查了伤口愈合的每个阶段，以便确定最重要的分子和生理差异，以及不同的损伤修复结果。了解这些强大的模型系统如何完成无疤痕愈合的壮举可能为治疗或预防纤维化提供关键的治疗方法。纤维化是一个严重的医学问题，在许多情况下仍未得到解决。然而，再生生物已经进化到可以避免纤维化，并且能够无疤痕愈合。本文回顾了纤维化和再生伤口愈合背后的生理和分子机制，并探讨了如何将这些知识应用于解决人类健康问题。
Soft tissue fibrosis and cutaneous scarring represent massive clinical burdens to millions of patients per year and the therapeutic options available are currently quite limited. Despite what is known about the process of fibrosis in mammals, novel approaches for combating fibrosis and scarring are necessary. It is hypothesized that scarring has evolved as a solution to maximize healing speed to reduce fluid loss and infection. This hypothesis, however, is complicated by regenerative animals, which have arguably the most remarkable healing abilities and are capable of scar‐free healing. This review explores the differences observed between adult mammalian healing that typically results in fibrosis versus healing in regenerative animals that heal scarlessly. Each stage of wound healing is surveyed in depth from the perspective of many regenerative and fibrotic healers so as to identify the most important molecular and physiological variances along the way to disparate injury repair outcomes. Understanding how these powerful model systems accomplish the feat of scar‐free healing may provide critical therapeutic approaches to the treatment or prevention of fibrosis. Fibrosis is a serious medical problem that remains unresolved in many cases. However, regenerative organisms have evolved to avoid fibrosis and are capable of scar‐free healing. Herein, the physiological and molecular mechanisms behind fibrosis and regenerative wound healing are reviewed and how this knowledge may be applied to solve issues in human health is explored.
登录
查看更多内容
影响因子：
6.9
作者：
Bergmeier, Vera;Etich, Julia;Brachvogel, Bent
通讯作者：
Brachvogel, Bent
DOI：
10.1016/j.bjps.2008.03.020
发表时间：
2008-01-01
影响因子：
2.7
作者：
Brown, B. C.;McKenna, S. P.;Bayat, A.
通讯作者：
Bayat, A.
影响因子：
64.5
作者：
Claudia Salzer, Marion;Lafzi, Atefeh;Aznar Benitah, Salvador
通讯作者：
Aznar Benitah, Salvador
影响因子：
7.2
作者：
Bryant, Donald M.;Sousounis, Konstantinos;Whited, Jessica L.
通讯作者：
Whited, Jessica L.
影响因子：
1.4
作者：
Abu-Hijleh, M. F.;Roshier, A. L.;Harris, P. F.
通讯作者：
Harris, P. F.