Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review.
Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review.
复制标题
DOI：
10.1016/j.genhosppsych.2013.01.006
复制
发表时间：
2013-05
影响因子：
7
通讯作者：
Wolf FM
中科院分区：
文献类型：
--
作者：
Park M;Katon WJ;Wolf FM
为了估计糖尿病患者随着时间的推移，伴随抑郁症的风险对全因死亡率的影响，我们对 Medline、CINAHL、Cochrane Library、Embase 和 Science Direct 数据库进行了整个 9 月份的检索。 2012 年 12 月 30 日。我们将搜索范围限制为纵向或前瞻性研究，报告患有抑郁症和糖尿病的患者的全因死亡率，与仅患有糖尿病的患者（以风险比作为主要结果）进行比较。两名评审员独立提取主要数据并使用预定标准评估研究质量。使用荟萃分析估计汇总的随机效应调整风险比（HR）。通过元回归检验调节变量对研究效应大小的影响。分析中共有来自 10 项研究的 42,363 名受访者。抑郁症与死亡风险显着相关（合并 HR：1.50，95% CI：1.35，1.66）。各项研究中几乎没有发现异质性的证据（Cochran Q：13.52，p 值：0.20，I2：26.03）。未检测到发表偏倚的显着可能性（Egger 回归截距：0.98，p 值：0.23）。抑郁症会显着增加糖尿病患者的死亡风险。早期发现和治疗抑郁症可能会改善该人群的健康状况。
To estimate risk of comorbid depression on all-cause mortality over time among individuals with diabetes Medline, CINAHL, Cochrane Library, Embase, and Science Direct database were searched through September. 30, 2012. We limited our search to longitudinal or prospective studies reporting all-cause mortality among those having depression and diabetes, compared with those having diabetes alone that used hazard ratios as the main outcome. Two reviewers independently extracted primary data and evaluated quality of studies using predetermined criteria. The pooled random effects adjusted hazard ratios (HRs) were estimated using meta-analysis. The impact of moderator variables on study effect size was examined with meta-regression. A total of 42,363 respondents from 10 studies were included in the analysis. Depression was significantly associated with risk of mortality (Pooled HRs: 1.50, 95% CI: 1.35, 1.66). Little evidence for heterogeneity was found across the studies (Cochran Q: 13.52, p-value: 0.20, I2: 26.03). No significant possibility of publication bias was detected (Egger’s regression intercept: 0.98, p-value: 0.23). Depression significantly increases the risk of mortality among individuals with diabetes. Early detection and treatment of depression may improve health outcomes in this population.
登录
查看更多内容
影响因子：
--
作者：
Grote, Nancy K.;Bridge, Jeffrey A.;Gavin, Amelia R.;Melville, Jennifer L.;Iyengar, Satish;Katon, Wayne J.
通讯作者：
Katon, Wayne J.
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
16.2
作者：
Egede, LE;Nietert, PJ;Zheng, D
通讯作者：
Zheng, D
影响因子：
8.2
作者：
Ahola, A. J.;Harjutsalo, V.;Groop, P. -H.
通讯作者：
Groop, P. -H.
影响因子：
8.2
作者：
Bruce, DG;Davis, WA;Davis, TME
通讯作者：
Davis, TME