alpha 2-Adrenergic receptors in human polymorphonuclear leukocyte membranes.
alpha 2-Adrenergic receptors in human polymorphonuclear leukocyte membranes.
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人多形核白细胞膜中的α2-肾上腺素能受体。
DOI：
10.1016/0006-2952(83)90233-2
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发表时间：
1983
影响因子：
5.8
通讯作者：
Marinetti,GV
中科院分区：
文献类型：
--
作者：
Panosian,JO;Marinetti,GV
Human polymorphonuclear cell membranes contain α2-adrenergic receptors which are measured by binding of the α2-adrenergic antagonist [3H]yohimbine. The α1-adrenergic antagonist [3H]prazosin showed no specific binding. High and low affinity sites were detected which hadKdvalues of 2.38 ± 0.4 and 139 ± 12 nM, respectively, and which bound maximally 4.82 ± 0.9 and 81 ± 9 fmoles of [3H]yohimbine/mg membrane protein. The high and low affinity sites were also detected by competition studies with phentolamine, epinephrine and norepinephrine and by dissociation kinetics of bound [3H]yohimbine. [3H]Yohimbine binding was stereospecifically inhibited by (−)- and (+)-epinephrine and norepinephrine. [3H]Yohimbine binding to intact cells showed about 500 high affinity sites per cell (Kd0.5 nM) and approximately 4000 lower affinity sites per cell (Kd3–4 nM). Yohimbine enhanced the (−)-norepinephrine stimulation of cAMP production in intact cells.
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证明 β2 肾上腺素受体在人中性粒细胞超声处理中具有高耦合效率。
DOI：
--
发表时间：
1980
期刊：
影响因子：
--
作者：
Galant Sp;Allred Sj
通讯作者：
Allred Sj
影响因子：
56.9
作者：
R. Snyderman;E. Goetzl
通讯作者：
R. Snyderman;E. Goetzl
血清包被的酵母聚糖可刺激人多形核白细胞中白三烯 B4 的合成。
DOI：
--
发表时间：
1981
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
--
作者：
Hans;Ulf Lundberg;Curt L. Malmsten
通讯作者：
Curt L. Malmsten
人血小板 α2-肾上腺素能受体：用 3H-育亨宾（一种选择性拮抗剂配体）标记
DOI：
--
发表时间：
1981
期刊：
影响因子：
--
作者：
M. Daiguji;H. Meltzer;D. U'prichard
通讯作者：
D. U'prichard
影响因子：
15.9
作者：
R. Wn;Ayne Alexander;Barry Cooper;Robert I. Handin
通讯作者：
Robert I. Handin