Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes.
Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes.
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DOI：
10.1002/dev.22329
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发表时间：
2022-12
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
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存在智力和发育障碍风险的整体发育迟缓儿童的早期触觉和伤害性（疼痛）机制尚不清楚。16名整体发育迟缓儿童（M年龄= 5.1岁，SD=1.4； 50%为男性）完成了改进的定量感觉测试（mQST）方案、表皮（皮肤）穿刺活检程序和家长认可的疼痛测量。报告慢性疼痛的儿童表皮神经纤维（ENF）密度明显高于无慢性疼痛的儿童。基于mQST试验，ENF密度值总体上与声音反应性增加有关，特别是在轻触和冷热刺激试验期间。研究结果支持了一种综合生物行为方法在标准化感觉测试中测试伤害和触觉外周神经支配和行为反应性的可行性，这些测试通常存在感觉功能障碍和适应性行为障碍的高风险样本。
Early tactile and nociceptive (pain) mechanisms in children with global developmental delay at risk for intellectual and developmental disability are not well understood. Sixteen children with global developmental delay (M age = 5.1 years, SD=1.4; 50% male) completed a modified quantitative sensory testing (mQST) protocol, an epidermal (skin) punch biopsy procedure, and parent-endorsed measures of pain. Children with reported chronic pain had significantly greater epidermal nerve fiber (ENF) density compared to children without chronic pain. Based on the mQST trials, ENF density values were associated with increased vocal reactivity overall and specifically during the light touch and cool thermal stimulus trials. The findings support the feasibility of an integrative bio-behavioral approach to test nociceptive and tactile peripheral innervation and behavioral reactivity during a standardized sensory test in a high-risk sample for which there is often sensory dysfunction and adaptive behavior impairments.
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