Cortical spatio-temporal dynamics underlying phonological target detection in humans.
Cortical spatio-temporal dynamics underlying phonological target detection in humans.
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DOI：
10.1162/jocn.2010.21466
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发表时间：
2011-06
影响因子：
3.2
通讯作者：
Knight RT
中科院分区：
文献类型：
--
作者：
Chang EF;Edwards E;Nagarajan SS;Fogelson N;Dalal SS;Canolty RT;Kirsch HE;Barbaro NM;Knight RT
选择性处理与任务相关的刺激对于目标导向的行为至关重要。我们使用皮质电图来评估简单语音目标检测任务期间皮质激活的时空动态，其中受试者在听到预先指定的目标音节声音时按下按钮。该任务期间的同步表面电位记录揭示了在不到 1 秒的时间内整个侧半球高伽马（HG，70-200 Hz）活动的高度有序的时间进展。该序列展示了颞上回（STG）和言语运动皮层中语音音节的并发区域感觉处理，然后过渡到从前额叶皮层（PFC）到手部感觉运动皮层的最终运动反应的顺序任务依赖处理。 STG 激活对于目标声音相对于非目标声音略有增强，支持早期感觉处理中的选择性增益机制，而 PFC 对目标完全有选择性，支持其在指导反应行为中的作用。这些结果表明，目标检测不是单一的认知事件，而是一个渐进的目标选择性过程，涉及感觉、认知和运动结构中的大规模快速并行和串行处理，以支持目标导向的人类行为。
Selective processing of task-relevant stimuli is critical for goal-directed behavior. We used electrocorticography to assess the spatio-temporal dynamics of cortical activation during a simple phonological target detection task, in which subjects press a button when a prespecified target syllable sound is heard. Simultaneous surface potential recordings during this task revealed a highly ordered temporal progression of high gamma (HG, 70– 200 Hz) activity across the lateral hemisphere in less than 1 sec. The sequence demonstrated concurrent regional sensory processing of speech syllables in the posterior superior temporal gyrus (STG) and speech motor cortex, and then transitioned to sequential task-dependent processing from prefrontal cortex (PFC), to the final motor response in the hand sensorimotor cortex. STG activation was modestly enhanced for target over nontarget sounds, supporting a selective gain mechanism in early sensory processing, whereas PFC was entirely selective to targets, supporting its role in guiding response behavior. These results reveal that target detection is not a single cognitive event, but rather a process of progressive target selectivity that involves large-scale rapid parallel and serial processing in sensory, cognitive, and motor structures to support goal-directed human behavior.
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影响因子：
56.9
作者：
HUBEL, DH;HENSON, CO;GALAMBOS, R
通讯作者：
GALAMBOS, R
影响因子：
56.9
作者：
FUSTER, JM;ALEXANDER, GE
通讯作者：
ALEXANDER, GE
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.2
作者：
Chao, LL;Knight, RT
通讯作者：
Knight, RT
影响因子：
5.7
作者：
Miller, Kai J.;denNijs, Marcel;Ojemann, Jeffrey G.
通讯作者：
Ojemann, Jeffrey G.