BCL-2 inhibition: stemming the tide of myeloid malignancies.

BCL-2 inhibition: stemming the tide of myeloid malignancies.
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DOI:
10.1016/j.stem.2013.02.006
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发表时间:
2013-03-07
期刊:
影响因子:
23.9
通讯作者:
Letai, Anthony
Letai, Anthony
中科院分区:
医学1区
文献类型:
--
作者:
Hogdal, Leah J.;Letai, Anthony

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Leukemia stem cells (LSC) are likely to be the source for both therapeutic resistance and relapse in myeloid malignancies. and find that LSC can be selectively targeted by small molecule antagonists of anti-apoptotic BCL-2 family proteins.
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