Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience.
Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience.
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DOI：
10.1155/2017/1546125
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发表时间：
2017
影响因子：
3.1
通讯作者：
Drolet G
中科院分区：
文献类型：
--
作者：
Henry MS;Gendron L;Tremblay ME;Drolet G
心理压力是由不利或苛刻的环境导致的精神或情绪紧张或紧张的状态。众所周知，慢性压力会诱发焦虑症和重度抑郁症;它也被认为是阿尔茨海默病的危险因素。压力恢复力是一个积极的结果，与保留的认知和健康的老龄化有关。复原力是个人内在的心理和生物特征，在面对逆境时提供保护，防止精神病理学的发展。我们如何促进或提高对慢性压力的适应力？许多研究提出了可能触发这一理想过程的机制。脑啡肽传递在控制疼痛、生理功能（如呼吸）和情感障碍中的作用已经研究了30多年。然而，它们在应对慢性压力方面的作用却很少受到关注。本文综述了脑啡肽通过其两种阿片受体μ阿片肽受体和δ阿片肽受体参与应激生活方式的自然适应的证据。
Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for Alzheimer's disease. Stress resilience is a positive outcome that is associated with preserved cognition and healthy aging. Resilience presents psychological and biological characteristics intrinsic to an individual conferring protection against the development of psychopathologies in the face of adversity. How can we promote or improve resilience to chronic stress? Numerous studies have proposed mechanisms that could trigger this desirable process. The roles of enkephalin transmission in the control of pain, physiological functions, like respiration, and affective disorders have been studied for more than 30 years. However, their role in the resilience to chronic stress has received much less attention. This review presents the evidence for an emerging involvement of enkephalin signaling through its two associated opioid receptors, μ opioid peptide receptor and δ opioid peptide receptor, in the natural adaptation to stressful lifestyles.
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影响因子：
10.6
作者：
Chu Sin Chung P;Keyworth HL;Martin-Garcia E;Charbogne P;Darcq E;Bailey A;Filliol D;Matifas A;Scherrer G;Ouagazzal AM;Gaveriaux-Ruff C;Befort K;Maldonado R;Kitchen I;Kieffer BL
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Kieffer BL
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5.3
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通讯作者：
Berton, Olivier
影响因子：
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Ciocchi, Stephane;Herry, Cyril;Luethi, Andreas
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影响因子：
64.8
作者：
BELLUZZI, JD;GRANT, N;STEIN, L
通讯作者：
STEIN, L
影响因子：
7.6
作者：
Berube, Patrick;Poulin, Jean-Francois;Drolet, Guy
通讯作者：
Drolet, Guy