Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil.
Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil.
复制标题
DOI：
10.1371/journal.pone.0250853
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Menezes RC
中科院分区：
文献类型：
--
作者：
Calvet GA;Pereira SA;Ogrzewalska M;Pauvolid-Corrêa A;Resende PC;Tassinari WS;Costa AP;Keidel LO;da Rocha ASB;da Silva MFB;Dos Santos SA;Lima ABM;de Moraes ICV;Mendes Junior AAV;Souza TDC;Martins EB;Ornellas RO;Corrêa ML;Antonio IMDS;Guaraldo L;Motta FDC;Brasil P;Siqueira MM;Gremião IDF;Menezes RC
家畜感染SARS-CoV-2与密切接触确诊为COVID-19的人类有关。目的：评估生活在SARS-CoV-2检测呈阳性的人类家庭中的狗和猫对SARS-CoV-2的暴露、感染和持续性，并调查与动物感染相关的临床和实验室变化。与COVID-19患者一起生活的动物被纵向跟踪，并收集鼻咽/口咽和直肠拭子并检测SARS-CoV-2。此外，采集血液样本进行实验室分析和空斑减少中和试验（PRNT 90），以研究特异性SARS-CoV-2抗体。2020年5月至10月，共排查21名患者的39只宠物（29只狗和10只猫）。来自10个（47.6%）家庭的9只狗（31%）和4只猫（40%）感染了SARS-CoV-2或血清学阳性。在人类指数COVID-19病例出现症状后11至51天，动物检测呈阳性。3只犬在相隔14、30和31天内两次检测呈阳性。在1只狗（3.4%）和2只猫（20%）中检测到SARS-CoV-2中和抗体。在这项研究中，13只动物中有6只感染了SARS-CoV-2或血清反应阳性，出现了轻微但可逆的疾病症状。使用逻辑回归分析，绝育，并与患病主人同床与宠物感染。在巴西里约热内卢的人类COVID-19病例家庭的狗和猫中发现了SARS-CoV-2感染的存在和持续性。COVID-19感染者应避免在患病期间与宠物密切接触。
Infection by SARS-CoV-2 in domestic animals has been related to close contact with humans diagnosed with COVID-19. Objectives: To assess the exposure, infection, and persistence by SARS-CoV-2 of dogs and cats living in the same households of humans that tested positive for SARS-CoV-2, and to investigate clinical and laboratory alterations associated with animal infection. Animals living with COVID-19 patients were longitudinally followed and had nasopharyngeal/oropharyngeal and rectal swabs collected and tested for SARS-CoV-2. Additionally, blood samples were collected for laboratory analysis, and plaque reduction neutralization test (PRNT90) to investigate specific SARS-CoV-2 antibodies. Between May and October 2020, 39 pets (29 dogs and 10 cats) of 21 patients were investigated. Nine dogs (31%) and four cats (40%) from 10 (47.6%) households were infected with or seropositive for SARS-CoV-2. Animals tested positive from 11 to 51 days after the human index COVID-19 case onset of symptoms. Three dogs tested positive twice within 14, 30, and 31 days apart. SARS-CoV-2 neutralizing antibodies were detected in one dog (3.4%) and two cats (20%). In this study, six out of thirteen animals either infected with or seropositive for SARS-CoV-2 have developed mild but reversible signs of the disease. Using logistic regression analysis, neutering, and sharing bed with the ill owner were associated with pet infection. The presence and persistence of SARS-CoV-2 infection have been identified in dogs and cats from households with human COVID-19 cases in Rio de Janeiro, Brazil. People with COVID-19 should avoid close contact with their pets during the time of their illness.
登录
查看更多内容
DOI：
10.3390/pathogens9090746
发表时间：
2020-09-11
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Musso N;Costantino A;La Spina S;Finocchiaro A;Andronico F;Stracquadanio S;Liotta L;Visalli R;Emmanuele G
通讯作者：
Emmanuele G
影响因子：
11.8
作者：
Barrs VR;Peiris M;Tam KWS;Law PYT;Brackman CJ;To EMW;Yu VYT;Chu DKW;Perera RAPM;Sit THC
通讯作者：
Sit THC
影响因子：
4.3
作者：
Sailleau, Corinne;Dumarest, Marine;Le Poder, Sophie
通讯作者：
Le Poder, Sophie
影响因子：
33.9
作者：
Newman, Alexandra;Smith, David;Behravesh, Casey Barton
通讯作者：
Behravesh, Casey Barton
影响因子：
4.3
作者：
Carlos, Renata Santiago Alberto;Mariano, Ana Paula Melo;Albuquerque, George Rego
通讯作者：
Albuquerque, George Rego