Facial morphometrics of children with non-syndromic orofacial clefts in Tanzania.
Facial morphometrics of children with non-syndromic orofacial clefts in Tanzania.
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坦桑尼亚的非综合性口腔裂缝儿童的面部形态计量学。
DOI：
10.1186/1472-6831-14-93
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发表时间：
2014-07-29
期刊：
影响因子：
2.9
通讯作者：
Hallgrimsson B
中科院分区：
文献类型：
--
作者：
Manyama M;Larson JR;Liberton DK;Rolian C;Smith FJ;Kimwaga E;Gilyoma J;Lukowiak KD;Spritz RA;Hallgrimsson B
口面裂（唇腭裂; CL/P）是最常见的先天性畸形之一，不同种族的患病率不同。在非非洲人群中，CL/P患者和健康对照者之间的颅面形状差异已被广泛报道。了解非洲人群中非综合征CL/P个体的颅面形状，将进一步了解非综合征口面裂中存在的种族和表型变异。在坦桑尼亚的Bugando医学中心进行了一项描述性横断面研究，比较了未修复的非综合征CL/P患者和无口面裂的正常人。使用非侵入性3D相机捕获三维（3D）面部表面。使用26个软组织标志的相应3D坐标来表征面部形状。基于Procrustes叠加数据，采用几何形态测量方法研究了组内和组间的面部形状变化。唇裂儿童的面部形状与对照组有显著差异，而不仅仅是唇裂本身。CL/P组鼻口宽度增加，眶间距增加，上颌前区的下颌骨更多。在CL/P组中，PCA显示面形变化与面高、鼻腔宽度、眶间距和面中突相关。单独唇裂（CL）和唇腭裂联合（CLP）组之间没有显著差异（Procrustes距离= 0.0416，p = 0.50）。CL/P组内的Procrustes距离排列检验显示单侧裂隙和双侧裂隙之间存在显著的形状差异（Procrustes距离= 0.0728，p = 0.0001）。我们的研究结果表明，形态学的变化是类似的CL/P患者和他们的非非洲人口的未受影响的近亲的研究。非综合征型CL/P的非洲儿童的平均面部形状与无口面裂的儿童有显著差异。主要差异包括眶间宽度、面宽和面中部多颌。我们观察到的面部形状差异的轴是相似的模式在高加索人群中看到的，尽管明显的差异，在裂缝的患病率和裂缝类型的分布。非洲和高加索人群中CL/P患者的面部形态相似，表明病因相似。
Orofacial clefts (cleft lip/palate; CL/P) are among the most common congenital anomalies, with prevalence that varies among different ethnic groups. Craniofacial shape differences between individuals with CL/P and healthy controls have been widely reported in non-African populations. Knowledge of craniofacial shape among individuals with non-syndromic CL/P in African populations will provide further understanding of the ethnic and phenotypic variation present in non-syndromic orofacial clefts. A descriptive cross-sectional study was carried out at Bugando Medical Centre, Tanzania, comparing individuals with unrepaired non-syndromic CL/P and normal individuals without orofacial clefts. Three-dimensional (3D) facial surfaces were captured using a non-invasive 3D camera. The corresponding 3D coordinates for 26 soft tissue landmarks were used to characterize facial shape. Facial shape variation within and between groups, based on Procrustes superimposed data, was studied using geometric morphometric methods. Facial shape of children with cleft lip differed significantly from the control group, beyond the cleft itself. The CL/P group exhibited increased nasal and mouth width, increased interorbital distance, and more prognathic premaxillary region. Within the CL/P group, PCA showed that facial shape variation is associated with facial height, nasal cavity width, interorbital distance and midfacial prognathism. The isolated cleft lip (CL) and combined cleft lip and palate (CLP) groups did not differ significantly from one another (Procrustes distance = 0.0416, p = 0.50). Procrustes distance permutation tests within the CL/P group showed a significant shape difference between unilateral clefts and bilateral clefts (Procrustes distance = 0.0728, p = 0.0001). Our findings indicate the morphological variation is similar to those of studies of CL/P patients and their unaffected close relatives in non-African populations. The mean facial shape in African children with non-syndromic CL/P differs significantly from children without orofacial clefts. The main differences involve interorbital width, facial width and midface prognathism. The axes of facial shape differences we observed are similar to the patterns seen in Caucasian populations, despite apparent differences in cleft prevalence and cleft type distribution. Similar facial morphology in individuals with CL/P in African and Caucasian populations suggests a similar aetiology.
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DOI：
10.1016/0002-9416(83)90178-1
发表时间：
1983-01-01
影响因子：
3
作者：
NAKASIMA, A;ICHINOSE, M
通讯作者：
ICHINOSE, M
影响因子：
1.1
作者：
Ferrario, VF;Sforza, C;Carù, A
通讯作者：
Carù, A
影响因子：
3.1
作者：
Naser-ud-Din, S.;Thoirs, K.;Sampson, W. J.
通讯作者：
Sampson, W. J.
DOI：
10.1046/j.1365-263x.2003.00496.x
发表时间：
2003-11-01
影响因子：
3.8
作者：
Hood, C A;Bock, M;Ayoub, A F
通讯作者：
Ayoub, A F
影响因子：
4
作者：
FRASER F C;PASHAYAN H
通讯作者：
PASHAYAN H