Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7.
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7.
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二甲双胍通过上调内质网谷胱甘肽过氧化物酶7来缓解人类细胞衰老
DOI：
10.1111/acel.12765
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发表时间：
2018-08
期刊：
影响因子：
7.8
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Fang J;Yang J;Wu X;Zhang G;Li T;Wang X;Zhang H;Wang CC;Liu GH;Wang L
Metformin, an FDA‐approved antidiabetic drug, has been shown to elongate lifespan in animal models. Nevertheless, the effects of metformin on human cells remain unclear. Here, we show that low‐dose metformin treatment extends the lifespan of human diploid fibroblasts and mesenchymal stem cells. We report that a low dose of metformin upregulates the endoplasmic reticulum‐localized glutathione peroxidase 7 (GPx7). GP×7 expression levels are decreased in senescent human cells, and GPx7 depletion results in premature cellular senescence. We also indicate that metformin increases the nuclear accumulation of nuclear factor erythroid 2‐related factor 2 (Nrf2), which binds to the antioxidant response elements in the GPX7 gene promoter to induce its expression. Moreover, the metformin‐Nrf2‐GPx7 pathway delays aging in worms. Our study provides mechanistic insights into the beneficial effects of metformin on human cellular aging and highlights the importance of the Nrf2‐GPx7 pathway in pro‐longevity signaling.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
DOI：
10.1083/jcb.201506123
发表时间：
2015-10-26
期刊：
The Journal of cell biology
影响因子：
--
作者：
Konno T;Pinho Melo E;Lopes C;Mehmeti I;Lenzen S;Ron D;Avezov E
通讯作者：
Avezov E
使用免整合患者来源的 iPSC 建模范可尼贫血发病机制和治疗方法
影响因子：
16.6
作者：
Liu, Guang-Hui;Suzuki, Keiichiro;Li, Mo;Qu, Jing;Montserrat, Nuria;Tarantino, Carolina;Gu, Ying;Yi, Fei;Xu, Xiuling;Zhang, Weiqi;Ruiz, Sergio;Plongthongkum, Nongluk;Zhang, Kun;Masuda, Shigeo;Nivet, Emmanuel;Tsunekawa, Yuji;Soligalla, Rupa Devi;Goebl, April;Aizawa, Emi;Kim, Na Young;Kim, Jessica;Dubova, Ilir;Li, Ying;Ren, Ruotong;Benner, Chris;del Sol, Antonio;Bueren, Juan;Pablo Trujillo, Juan;Surralles, Jordi;Cappelli, Enrico;Dufour, Carlo;Esteban, Concepcion Rodriguez;Belmonte, Juan Carlos Izpisua
通讯作者：
Belmonte, Juan Carlos Izpisua
影响因子：
14.8
作者：
Dahl, John Arne;Collas, Philippe
通讯作者：
Collas, Philippe
影响因子：
3
作者：
Li, Chenyang;Shi, Liang;Zhao, Mingwen
通讯作者：
Zhao, Mingwen