The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients.
The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients.
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按性别、吸烟状况和种族划分的非小细胞肺癌患者体重指数与总存活率的关系：一项对20,937名国际肺癌联盟(ILCCO)患者的综合分析。
DOI：
10.1016/j.lungcan.2020.11.029
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Liu G
中科院分区：
文献类型：
--
作者：
Jiang M;Fares AF;Shepshelovich D;Yang P;Christiani D;Zhang J;Shiraishi K;Ryan BM;Chen C;Schwartz AG;Tardon A;Shete S;Schabath MB;Teare MD;Le Marchand L;Zhang ZF;Field JK;Brenner H;Diao N;Xie J;Kohno T;Harris CC;Wenzlaff AS;Fernandez-Tardon G;Ye Y;Taylor F;Wilkens LR;Davies M;Liu Y;Barnett MJ;Goodman GE;Morgenstern H;Holleczek B;Thomas S;Brown MC;Hung RJ;Xu W;Liu G
身体质量指数（BMI）与肺癌预后的关系是不均匀的。我们评估了性别、吸烟和种族对非小细胞肺癌（NSCLC）患者BMI和总生存期（OS）之间关系的影响。来自16个个体ILCCO研究的数据被汇总，以评估BMI与以下因素对OS的相互作用：自我报告的种族、吸烟状况和性别，使用Cox模型（校正风险比；aHR），并在分层分析中调整惩罚平滑样条图。在有BMI值的20937例NSCLC患者中，女性占47%；从不吸烟= 14%；白人患者= 76%。BMI显示不同种族的生存差异，与BMI正常的患者相比，体重过轻与白人患者的生存差有关（OS, aHR = 1.66），而与黑人患者无关（aHR = 1.06； p相互作用= 0.02）。超重/肥胖的黑人NSCLC患者与正常体重的患者相比，超重/肥胖的黑人NSCLC患者的OS也相对较好（p - interaction = 0.06）。在亚洲患者和从不吸烟的患者中，BMI与生存率的关系最小。与男性吸烟者相比，BMI指数极端的女性吸烟者在体重不足（p交互作用<0.001）和肥胖（p交互作用= 0.004）方面的结果都比正常BMI类别的男性吸烟者更差。白人患者中体重过轻和肥胖的女性吸烟者的预后较差。在亚洲患者和从不吸烟的患者中没有观察到这些BMI关联。与白人患者相比，黑人患者在BMI极值方面有更有利的结果。黑人患者的身体组成，以及更常见于亚洲患者和从不吸烟者的非小细胞肺癌亚型，可能解释了BMI-OS关系的差异。
The relationship between Body-Mass-Index (BMI) and lung cancer prognosis is heterogeneous. We evaluated the impact of sex, smoking and race on the relationship between BMI and overall survival (OS) in non-small-cell-lung-cancer (NSCLC). Data from 16 individual ILCCO studies were pooled to assess interactions between BMI and the following factors on OS: self-reported race, smoking status and sex, using Cox models (adjusted hazard ratios; aHR) with interaction terms and adjusted penalized smoothing spline plots in stratified analyses. Among 20,937 NSCLC patients with BMI values, females = 47 %; never-smokers = 14 %; White-patients = 76 %. BMI showed differential survival according to race whereby compared to normal-BMI patients, being underweight was associated with poor survival among white patients (OS, aHR = 1.66) but not among black patients (aHR = 1.06; pinteraction = 0.02). Comparing overweight/obese to normal weight patients, Black NSCLC patients who were overweight/obese also had relatively better OS (pinteraction = 0.06) when compared to White-patients. BMI was least associated with survival in Asian-patients and never-smokers. The outcomes of female ever-smokers at the extremes of BMI were associated with worse outcomes in both the underweight (pinteraction<0.001) and obese categories (pinteraction = 0.004) relative to the normal-BMI category, when compared to male ever-smokers. Underweight and obese female ever-smokers were associated with worse outcomes in White-patients. These BMI associations were not observed in Asian-patients and never-smokers. Black-patients had more favorable outcomes in the extremes of BMI when compared to White-patients. Body composition in Black-patients, and NSCLC subtypes more commonly seen in Asian-patients and never-smokers, may account for differences in these BMI-OS relationships.
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影响因子：
10.3
作者：
Desrichard, Alexis;Kuo, Fengshen;Morris, Luc G. T.
通讯作者：
Morris, Luc G. T.
影响因子：
8.4
作者：
Cote, Michele L.;Liu, Mei;Bonassi, Stefano;Neri, Monica;Schwartz, Ann G.;Christiani, David C.;Spitz, Margaret R.;Muscat, Joshua E.;Rennert, Gad;Aben, Katja K.;Andrew, Angeline S.;Bencko, Vladimir;Bickeboeller, Heike;Boffetta, Paolo;Brennan, Paul;Brenner, Hermann;Duell, Eric J.;Fabianova, Eleonora;Field, John K.;Foretova, Lenka;Friis, Soren;Harris, Curtis C.;Holcatova, Ivana;Hong, Yun-Chul;Isla, Dolores;Janout, Vladimir;Kiemeney, Lambertus A.;Kiyohara, Chikako;Lan, Qing;Lazarus, Philip;Lissowska, Jolanta;Le Marchand, Loic;Mates, Dana;Matsuo, Keitaro;Mayordomo, Jose I.;McLaughlin, John R.;Morgenstern, Hal;Mueeller, Heiko;Orlow, Irene;Park, Bernard J.;Pinchev, Mila;Raji, Olaide Y.;Rennert, Hedy S.;Rudnai, Peter;Seow, Adeline;Stucker, Isabelle;Szeszenia-Dabrowska, Neonila;Teare, M. Dawn;Tjonnelan, Anne;Ugolini, Donatella;van der Heijden, Henricus F. M.;Wichmann, Erich;Wiencke, John K.;Woll, Penella J.;Yang, Ping;Zaridze, David;Zhang, Zuo-Feng;Etzel, Carol J.;Hung, Rayjean J.
通讯作者：
Hung, Rayjean J.
DOI：
10.1158/1078-0432.ccr-15-3101
发表时间：
2016-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Gainor JF;Shaw AT;Sequist LV;Fu X;Azzoli CG;Piotrowska Z;Huynh TG;Zhao L;Fulton L;Schultz KR;Howe E;Farago AF;Sullivan RJ;Stone JR;Digumarthy S;Moran T;Hata AN;Yagi Y;Yeap BY;Engelman JA;Mino-Kenudson M
通讯作者：
Mino-Kenudson M
影响因子：
5.7
作者：
Eilers, PHC;Marx, BD
通讯作者：
Marx, BD
影响因子：
6.4
作者：
Ben Khedher, Soumaya;Neri, Monica;Stuker, Isabelle
通讯作者：
Stuker, Isabelle