Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits.
Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits.
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胆固醇酯转移蛋白的过度表达增加转基因兔动脉粥样硬化病变中巨噬细胞衍生的泡沫细胞积累
DOI：
10.1155/2017/3824276
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发表时间：
2017
影响因子：
4.6
通讯作者：
Liu E
中科院分区：
文献类型：
--
作者：
Gao S;Wang X;Cheng D;Li J;Li L;Ran L;Zhao S;Fan J;Liu E
High levels of plasma high-density lipoprotein-cholesterol (HDL-C) are inversely associated with the risk of atherosclerosis and other cardiovascular diseases; thus, pharmacological inhibition of cholesteryl ester transfer protein (CETP) is considered to be a therapeutic method of raising HDL-C levels. However, many CETP inhibitors have failed to achieve a clinical benefit despite raising HDL-C. In the study, we generated transgenic (Tg) rabbits that overexpressed the human CETP gene to examine the influence of CETP on the development of atherosclerosis. Both Tg rabbits and their non-Tg littermates were fed a high cholesterol diet for 16 weeks. Plasma lipids and body weight were measured every 4 weeks. Gross lesion areas of the aortic atherosclerosis along with lesional cellular components were quantitatively analyzed. Overexpression of human CETP did not significantly alter the gross atherosclerotic lesion area, but the number of macrophages in lesions was significantly increased. Overexpression of human CETP did not change the plasma levels of total cholesterol or low-density lipoprotein cholesterol but lowered plasma HDL-C and increased triglycerides. These data revealed that human CETP may play an important role in the development of atherosclerosis mainly by decreasing HDL-C levels and increasing the accumulation of macrophage-derived foam cells.
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影响因子：
8.7
作者：
Kuivenhoven, JA;deKnijff, P;Pritchard, PH
通讯作者：
Pritchard, PH
影响因子：
39.3
作者：
Chapman MJ;Le Goff W;Guerin M;Kontush A
通讯作者：
Kontush A
影响因子：
158.5
作者：
Kastelein, John J. P.;van Leuven, Sander I.;Bots, Michiel L.
通讯作者：
Bots, Michiel L.
DOI：
10.1161/01.atv.12.6.736
发表时间：
1992-06-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
MAROTTI, KR;CASTLE, CK;MELCHIOR, GW
通讯作者：
MELCHIOR, GW
影响因子：
--
作者：
Barter, PJ
通讯作者：
Barter, PJ