Principal Postulates of Centrosomal Biology. Version 2020.

Principal Postulates of Centrosomal Biology. Version 2020.
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DOI:
10.3390/cells9102156
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发表时间:
2020-09-24
期刊:
影响因子:
6
通讯作者:
Avidor-Reiss T
Avidor-Reiss T
中科院分区:
生物学2区
文献类型:
--
作者:
Uzbekov RE;Avidor-Reiss T

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中心体是一种独特的结构,它由两个中心粒组成,周围环绕着中心粒周围的物质,在从单细胞藻类到哺乳动物的各种分类群的生物体中,经过10亿年的进化,中心体保留了其主要特征。除了在有丝分裂和分裂间期组织微管系统的功能外,中心体还执行许多其他细胞功能。特别是中心粒是敏感的初级纤毛和运动纤毛和鞭毛形成的基础。中心体的另一个主要功能是将负责细胞沿着细胞周期进程的调节蛋白集中在一个地方。尽管存在例外,中心体的功能受到一般原则,这是在这次审查中讨论。
The centrosome, which consists of two centrioles surrounded by pericentriolar material, is a unique structure that has retained its main features in organisms of various taxonomic groups from unicellular algae to mammals over one billion years of evolution. In addition to the most noticeable function of organizing the microtubule system in mitosis and interphase, the centrosome performs many other cell functions. In particular, centrioles are the basis for the formation of sensitive primary cilia and motile cilia and flagella. Another principal function of centrosomes is the concentration in one place of regulatory proteins responsible for the cell’s progression along the cell cycle. Despite the existing exceptions, the functioning of the centrosome is subject to general principles, which are discussed in this review.
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