Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations.
Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations.
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DOI：
10.1093/nar/gkab807
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发表时间：
2021-10-11
影响因子：
14.9
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Dai S;Qu L;Li J;Chen Y
Forkhead box(Fox)蛋白是一个进化上保守的转录因子家族，在真核生物的发育和成体过程中发挥着众多的调节作用。Fox蛋白的功能障碍与多种人类疾病有关，包括癌症、神经发育障碍和遗传性疾病。狐狸家族成员共有一个高度保守的DNA结合域(DBD)，这是DNA识别、结合和功能所必需的。自1993年解决第一个福克斯结构以来，迄今已报告了30个福克斯结构。现在很明显，FOX成员之间的结构和DNA识别机制不同；然而，缺乏对这方面的系统综述。在这篇手稿中，我们概述了FOX转录因子与DNA结合的机制，包括蛋白质结构、DNA结合特性和致病突变。这篇综述将使基础研究人员和临床医生能够更好地了解Fox家族转录因子。
Forkhead box (FOX) proteins are an evolutionarily conserved family of transcription factors that play numerous regulatory roles in eukaryotes during developmental and adult life. Dysfunction of FOX proteins has been implicated in a variety of human diseases, including cancer, neurodevelopment disorders and genetic diseases. The FOX family members share a highly conserved DNA-binding domain (DBD), which is essential for DNA recognition, binding and function. Since the first FOX structure was resolved in 1993, >30 FOX structures have been reported to date. It is clear now that the structure and DNA recognition mechanisms vary among FOX members; however, a systematic review on this aspect is lacking. In this manuscript, we present an overview of the mechanisms by which FOX transcription factors bind DNA, including protein structures, DNA binding properties and disease-causing mutations. This review should enable a better understanding of FOX family transcription factors for basic researchers and clinicians.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
DOI：
10.1126/science.1162327
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badis G;Berger MF;Philippakis AA;Talukder S;Gehrke AR;Jaeger SA;Chan ET;Metzler G;Vedenko A;Chen X;Kuznetsov H;Wang CF;Coburn D;Newburger DE;Morris Q;Hughes TR;Bulyk ML
通讯作者：
Bulyk ML
DOI：
10.1107/s0907444910042228
发表时间：
2010-12-01
期刊：
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
影响因子：
--
作者：
Boura, Evzen;Rezabkova, Lenka;Obsil, Tomas
通讯作者：
Obsil, Tomas
影响因子：
64.8
作者：
CLARK, KL;HALAY, ED;BURLEY, SK
通讯作者：
BURLEY, SK