The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases.
The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases.
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DOI：
10.3389/fmicb.2012.00323
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发表时间：
2012
影响因子：
5.2
通讯作者：
Utsunomiya A
中科院分区：
文献类型：
--
作者：
Kannagi M;Hasegawa A;Takamori A;Kinpara S;Utsunomiya A
人类T细胞白血病病毒1型（HTLV-1）可导致成人T细胞白血病（ATL）和HTLV-1相关的脊髓病/热带痉挛性下肢轻瘫的HTLV-1携带者的小子集。HTLV-1特异性T细胞应答在HTLV-1感染期间的抗病毒和抗肿瘤宿主防御中起关键作用。一些HTLV-1携带者在无症状阶段表现出HTLV-1特异性T细胞的选择性丧失或无反应性。这也在ATL患者中观察到，因此可能是ATL与前病毒负荷升高联合的潜在风险因素。HTLV-1特异性T细胞通常识别病毒癌蛋白Tax，表明Tax蛋白在体内表达，尽管已知HTLV-1基因表达水平非常低。HTLV-1感染的细胞可诱导I型干扰素（IFN）应答，并在体外抑制HTLV-1表达，表明I型IFN应答在体内病毒抑制和发病机制中的作用。获得性和先天性免疫应答控制HTLV-1感染细胞的状态，并且可能是HTLV-1介导的恶性和炎性疾病发展的重要决定因素。
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis in small subsets of HTLV-1 carriers. HTLV-1-specific T-cell responses play critical roles in anti-viral and anti-tumor host defense during HTLV-1 infections. Some HTLV-1 carriers exhibit selective loss or anergy of HTLV-1-specific T-cells at an asymptomatic stage. This is also observed in ATL patients and may therefore be an underlying risk factor of ATL in combination with elevated proviral loads. HTLV-1-specific T-cells often recognize the viral oncoprotein Tax, indicating expression of Tax protein in vivo, although levels of HTLV-1 gene expression are known to be very low. A type-I interferon (IFN) response can be induced by HTLV-1-infected cells and suppresses HTLV-1 expression in vitro, suggesting a role of type-I IFN response in viral suppression and pathogenesis in vivo. Both acquired and innate immune responses control the status of HTLV-1-infected cells and could be the important determinants in the development of HTLV-1-mediated malignant and inflammatory diseases.
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DOI：
10.1073/pnas.82.8.2277
发表时间：
1985-01-01
影响因子：
11.1
作者：
FUJISAWA, J;SEIKI, M;YOSHIDA, M
通讯作者：
YOSHIDA, M
影响因子：
4.4
作者：
Goon, PKC;Igakura, T;Bangham, CRM
通讯作者：
Bangham, CRM
影响因子：
6.4
作者：
Abdelbary, Nashwa H.;Abdullah, Hazem M.;Kubota, Ryuji
通讯作者：
Kubota, Ryuji
影响因子：
5.4
作者：
Feng, X;Heyden, NV;Ratner, L
通讯作者：
Ratner, L
DOI：
10.1073/pnas.78.10.6476
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HINUMA, Y;NAGATA, K;MIYOSHI, I
通讯作者：
MIYOSHI, I