In vivoneutron activation assembly design for quantification of trace elements using MCNP.
In vivoneutron activation assembly design for quantification of trace elements using MCNP.
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DOI：
10.1088/1361-6579/abc322
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发表时间：
2020-12-28
影响因子：
3.2
通讯作者：
Nie LH
中科院分区：
文献类型：
--
作者：
Tabbassum S;Nie LH
微量元素和必需元素在维持人体正常细胞和器官功能方面起着至关重要的作用，而其中一些元素的异常暴露也可能与疾病有关，例如锰中毒。为了研究元素摄入量与健康结果之间的关系，准确评估人体中元素的吸收和储存至关重要。基于中子活化分析的技术可用于微量元素的体内测量，前提是测量系统保证在可接受剂量下的低检测限。本研究的目的是设计和优化一个定制的和便携式氘-氘中子发生器为基础的辐照组件的微量元素在体内的中子活化分析，使用蒙特卡罗模拟。辐照组件包括减速器、快中子过滤器、反射器和屏蔽。用锰（Mn）和钾（K）掺杂的人手模型测定了各元素的系统灵敏度和检出限。计算的检测限为0.16 μg Mn/g干骨（ppm）的Mn和17 ppm的K，与36 mSv的等效剂量的手为10分钟的照射。这种更灵敏的体内中子活化分析系统将检测体内微量元素。
Trace and essential elements both play a crucial role in maintaining normal cellular and organ functions in human, while abnormal exposure to some of them is also potentially related to diseases, e.g. manganism. To study the association between elemental intake and health outcomes, accurate assessment of elemental uptake and storage in the human body is essential. Technology based on neutron activation analysis can be used for in vivo measurement of the trace elements given that the measurement system guarantees a low detection limit with an acceptable dose. This study aims to design and optimize a customized and portable deuterium–deuterium neutron generator-based irradiation assembly for the NAA of trace elements in vivo, using Monte Carlo simulations. The irradiation assembly includes a moderator, a fast neutron filter, a reflector, and shielding. The human hand phantoms doped with manganese (Mn) and potassium (K) are used to determine the respective elements’ system sensitivity and detection limit. The calculated detection limit is 0.16 μg Mn per gram dry bone (ppm) for Mn and 17 ppm for K, with an equivalent dose of 36 mSv to the hand for 10 min irradiation. This more sensitive in vivo neutron activation analysis system will detect trace elements in vivo.
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DOI：
10.1016/0168-9002(85)90033-6
发表时间：
1985-01-01
影响因子：
1.4
作者：
IKEDA, S;CARPENTER, JM
通讯作者：
CARPENTER, JM
影响因子：
3.5
作者：
Aslam;Pejovic-Milic, A.;McNeill, F. E.
通讯作者：
McNeill, F. E.
影响因子：
6.1
作者：
Mildner, DFR;Lamaze, GP
通讯作者：
Lamaze, GP
影响因子：
1.7
作者：
BAKER, DE
通讯作者：
BAKER, DE
影响因子：
3.5
作者：
Aslam;Chettle, D. R.;Waker, A. J.
通讯作者：
Waker, A. J.