Inflammasome-Dependent Coagulation Activation in Sepsis.
Inflammasome-Dependent Coagulation Activation in Sepsis.
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脓毒症中炎症小体依赖性凝血激活。
DOI：
10.3389/fimmu.2021.641750
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发表时间：
2021
影响因子：
7.3
通讯作者：
Kang R
中科院分区：
文献类型：
--
作者：
Wu R;Wang N;Comish PB;Tang D;Kang R
脓毒症是由宿主对感染的反应失调引起的潜在危及生命的病理状况。在病理学上，全身性炎症可启动凝血激活，导致器官功能障碍，并最终导致多器官衰竭和脓毒性死亡。炎性小体是胞质多蛋白信号传导复合物，其控制宿主对来自微生物的不同病原体相关分子模式（PAMP）以及来自死亡或垂死宿主细胞的损伤相关分子模式（DAMP）的反应。最近的研究强调，典型和非典型炎性小体的激活不仅介导白细胞介素-1（IL-1）家族细胞因子的成熟和分泌，而且还触发激活的巨噬细胞和单核细胞中的凝血因子III、组织因子（F3，最好称为TF）的释放。免疫凝固中炎性小体的这些新兴功能进一步受到干扰素应答cGAMP相互作用物1（STING 1，也称为STING或TMEM 173，先天免疫信号传导网络的枢纽）和高迁移率族蛋白1（HMG B1，核DAMP）的刺激物的正调控。本文就炎症体依赖性凝血激活在脓毒症中的调节和作用作一简要综述。
Sepsis is a potentially life-threatening, pathological condition caused by a dysregulated host response to infection. Pathologically, systemic inflammation can initiate coagulation activation, leading to organ dysfunction, and ultimately to multiple organ failure and septic death. The inflammasomes are cytosolic multiprotein signaling complexes that control the host response to diverse pathogen-associated molecular patterns (PAMPs) from microorganisms as well as damage-associated molecular patterns (DAMPs) from dead or dying host cells. Recent studies highlight that the activation of canonical and non-canonical inflammasomes not only mediate the maturation and secretion of interleukin-1 (IL1) family cytokines, but also trigger the release of coagulation factor III, tissue factor (F3, best known as TF) in activated macrophages and monocytes. These emerging functions of inflammasomes in immunocoagulation are further positively regulated by stimulator of interferon response cGAMP interactor 1 (STING1, also known as STING or TMEM173, a hub of the innate immune signaling network) and high mobility group box 1 (HMGB1, a nuclear DAMP). This mini-review will discuss the regulation and function of inflammasome-dependent coagulation activation in sepsis.
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形成孔的蛋白质加油D可以调节白细胞介素-1的巨噬细胞分泌。
影响因子：
32.4
作者：
Evavold CL;Ruan J;Tan Y;Xia S;Wu H;Kagan JC
通讯作者：
Kagan JC
DOI：
10.1186/cc13163
发表时间：
2013-12-16
期刊：
Critical care (London, England)
影响因子：
--
作者：
Gando S;Saitoh D;Ishikura H;Ueyama M;Otomo Y;Oda S;Kushimoto S;Tanjoh K;Mayumi T;Ikeda T;Iba T;Eguchi Y;Okamoto K;Ogura H;Koseki K;Sakamoto Y;Takayama Y;Shirai K;Takasu O;Inoue Y;Mashiko K;Tsubota T;Endo S;Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group for the JAAM DIC Antithrombin Trial (JAAMDICAT)
通讯作者：
Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group for the JAAM DIC Antithrombin Trial (JAAMDICAT)
影响因子：
16.6
作者：
Chu LH;Indramohan M;Ratsimandresy RA;Gangopadhyay A;Morris EP;Monack DM;Dorfleutner A;Stehlik C
通讯作者：
Stehlik C
DOI：
10.1126/science.1240988
发表时间：
2013-09-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hagar JA;Powell DA;Aachoui Y;Ernst RK;Miao EA
通讯作者：
Miao EA
影响因子：
64.8
作者：
Kofoed, Eric M.;Vance, Russell E.
通讯作者：
Vance, Russell E.