Metabolic alterations: a biomarker for radiation-induced normal brain injury-an MR spectroscopy study.
Metabolic alterations: a biomarker for radiation-induced normal brain injury-an MR spectroscopy study.
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DOI：
10.1002/jmri.21657
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发表时间：
2009-02
影响因子：
4.4
通讯作者：
Cao, Y.
中科院分区：
文献类型：
--
作者：
Sundgren, P. C.;Nagesh, V.;Elias, A.;Tsien, C.;Junck, L.;Hassan, D. M. Gomez;Lawrence, T. S.;Chenevert, T. L.;Rogers, L.;McKeever, P.;Cao, Y.
目的探讨放射治疗（RT）后正常脑组织代谢状态的变化是否可以用二维CSI（chemical shift imaging，化学位移成像）质子spectroscopic.Materials and Methods 11例接受颅脑放射治疗（RT）的原发性脑肿瘤患者。在RT之前、期间和之后进行2D-CSI MRS，参数如下：TE/TR 144/1500 ms，视野（FOV）24，厚度10 mm，矩阵16 × 16。结果放疗后1个月、6个月及放疗后第3周，正常脑组织的胆碱/肌酸（Cho/Cr）、N-乙酰天门冬氨酸（NAA）/Cr、NAA/Cho比值均较放疗前显著降低（P<0. 01）。与RT前值1.43 ± 0.04相比，RT第3周时NAA/Cr比值降低了−0.19 ± 0.05（平均值±标准误[SE]），RT最后一周时降低了−0.14 ± 0.06，RT后1个月时降低了−0.14 ± 0.05，RT后6个月时降低了−0.30 ± 0.08。Cho/Cr比值从RT前值1.29 ± 0.03下降到RT第3周时的−0.27 ± 0.05，RT最后一周时的−0.11 ± 0.05，RT后1个月时的−0.26 ± 0.05和RT后6个月时的−0.25 ± 0.07。放射治疗3周、最后一周及治疗后1个月Cho/Cr的变化与放射剂量和剂量体积的相互作用有关（P< 0.005）。结论MRS可检测正常受照脑组织的早期代谢变化。J.磁共振Imaging 2009;29：291-297.© 2009 Wiley利斯公司
PurposeTo assess if interval changes in metabolic status in normal cerebral tissue after radiation therapy (RT) can be detected by 2D CSI (chemical shift imaging) proton spectroscopy.Materials and MethodsEleven patients with primary brain tumors undergoing cranial radiation therapy (RT) were included. 2D‐CSI MRS was performed before, during, and after the course of RT with the following parameters: TE/TR 144/1500 ms, field of view (FOV) 24, thickness 10 mm, matrix 16 × 16. The metabolic ratios choline/creatine (Cho/Cr), N‐acetylaspartate (NAA)/Cr, and NAA/Cho in normal brain tissue were calculated.ResultsNAA/Cr and Cho/Cr were significantly decreased at week 3 during RT and at 1 month and 6 months after RT compared to values prior to RT (P< 0.01). The NAA/Cr ratio decreased by −0.19 ± 0.05 (mean ± standard error [SE]) at week 3 of RT, −0.14 ± 0.06 at the last week of RT, −0.14 ± 0.05 at 1 month after RT, and −0.30 ± 0.08 at 6 months after RT compared to the pre‐RT value of 1.43 ± 0.04. The Cho/Cr ratio decreased by −0.27 ± 0.05 at week 3 of RT, −0.11 ± 0.05 at the last week of RT, −0.26 ± 0.05 at 1 month after RT and −0.25 ± 0.07 at 6 months after RT from the pre‐RT value of 1.29 ± 0.03. Changes in Cho/Cr were correlated with the interaction of the radiation dose and dose‐volume at week 3 of RT, during the last week of RT (P< 0.005), and at 1 month after RT (P= 0.017).ConclusionThe results of this study suggest that MRS can detect early metabolic changes in normal irradiated brain tissue. J. Magn. Reson. Imaging 2009;29:291–297. © 2009 Wiley‐Liss, Inc.
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DOI：
10.1016/s0360-3016(97)00714-1
发表时间：
1998-01-15
影响因子：
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作者：
Estève, F;Rubin, C;Le Bas, JF
通讯作者：
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DOI：
10.1097/00000421-200306000-00014
发表时间：
2003-06-01
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