Repeated restraint stress lowers the threshold for response to third ventricle CRF administration.
Repeated restraint stress lowers the threshold for response to third ventricle CRF administration.
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DOI：
10.1016/j.yhbeh.2016.12.008
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发表时间：
2017-03
影响因子：
3.5
通讯作者：
Harris RB
中科院分区：
文献类型：
--
作者：
Harris RB
大鼠和小鼠暴露于重复的压力或一个单一的严重的压力表现出持续增加的精力，内分泌和行为反应，随后的新的温和的压力。本研究测试了高反应性是否是由于对促肾上腺皮质激素释放因子（CRF）的反应阈值降低或对标准剂量CRF的反应过度所致。雄性Sprague道利大鼠在连续3天（RRS）中每天接受3小时束缚，或作为非束缚对照。RRS引起暂时性食欲减退，但体重持续下降。束缚结束后8天，大鼠接受剂量递增的CRF（0- 3.0 μg）。最低剂量CRF（0.25 μg）可增加RRS大鼠皮质酮的释放，而对照组大鼠无此作用。较高剂量在两组大鼠中引起相同的皮质酮刺激。束缚结束后15天，大鼠在光照期禁食，并在黑暗期开始时接受剂量递增的第三脑室CRF。最低剂量的CRF在输注后的第一个小时内抑制RRS大鼠的摄食，但不抑制对照大鼠的摄食。在RRS和对照大鼠中，所有其他剂量的CRF对摄食量的抑制程度相同。RRS大鼠对中枢CRF反应阈值的降低与束缚后对CRF的慢性高反应性和轻度应激一致。
Rats and mice exposed to repeated stress or a single severe stress exhibit a sustained increase in energetic, endocrine and behavioral response to subsequent novel mild stress. This study tested whether the hyper-responsiveness was due to a lowered threshold of response to corticotropin releasing factor (CRF) or an exaggerated response to a standard dose of CRF. Male Sprague Dawley rats were subjected to 3 hours of restraint on each of 3 consecutive days (RRS) or were non-restrained Controls. RRS caused a temporary hypophagia, but a sustained reduction in body weight. Eight days after the end of restraint rats received increasing third ventricle doses of CRF (0- 3.0 μg). The lowest dose of CRF (0.25 μg) increased corticosterone release in RRS, but not Control rats. Higher doses caused the same stimulation of corticosterone in the two groups of rats. Fifteen days after the end of restraint rats were food deprived during the light period and received increasing third ventricle doses of CRF at the start of the dark period. The lowest dose of CRF inhibited food intake during the first hour following infusion in RRS, but not Control rats. All other doses of CRF inhibited food intake to the same degree in both RRS and Control rats. The lowered threshold of response to central CRF is consistent with the chronic hyper-responsiveness to CRF and mild stress in RRS rats during the post-restraint period.
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影响因子：
1.9
作者：
Watt, Michael J.;Burke, Andrew R.;Renner, Kenneth J.;Forster, Gina L.
通讯作者：
Forster, Gina L.
影响因子：
3.3
作者：
CURTIS, AL;PAVCOVICH, LA;VALENTINO, RJ
通讯作者：
VALENTINO, RJ
DOI：
10.1523/jneurosci.0450-11.2011
发表时间：
2011-04-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Wohleb ES;Hanke ML;Corona AW;Powell ND;Stiner LM;Bailey MT;Nelson RJ;Godbout JP;Sheridan JF
通讯作者：
Sheridan JF
影响因子：
3.3
作者：
Berton, O;Durand, M;Chaouloff, F
通讯作者：
Chaouloff, F
DOI：
10.1186/1744-9081-9-39
发表时间：
2013-10-17
期刊：
Behavioral and brain functions : BBF
影响因子：
--
作者：
Novick AM;Miiller LC;Forster GL;Watt MJ
通讯作者：
Watt MJ