Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults.
Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults.
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DOI：
10.1037/a0015752
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发表时间：
2009-06
影响因子：
1.9
通讯作者：
Forster, Gina L.
中科院分区：
文献类型：
--
作者：
Watt, Michael J.;Burke, Andrew R.;Renner, Kenneth J.;Forster, Gina L.
青春期的社会压力与成年早期精神病理学的出现相关。在这项研究中，我们调查了青春期中期社会失败压力对成年男性大脑和行为的影响。将青春期雄性Sprague-Dawley大鼠暴露于反复的社会失败中五天，而对照组被置于一个新的空笼子中。当暴露于失败相关的线索作为成年人，以前失败的大鼠表现出增加的风险评估和行为抑制，表现出长期记忆的失败背景。然而，先前失败的大鼠在高架十字迷宫和旷场测试中表现出增加的运动，这表明增加了新奇诱导的行为。青春期的失败也影响了成年人应激反应边缘区的单胺水平，导致内侧前额叶皮质多巴胺减少，腹侧齿状回去甲肾上腺素和5-羟色胺增加，中缝背核去甲肾上腺素减少。我们的研究结果表明，青少年社交失败产生的赤字在焦虑反应和改变单胺能功能在成年期。这个模型提供了潜在的识别严重的青少年社会压力，可能有助于增加成年男性的心理病理脆弱性引起的具体机制。
Social stress in adolescence is correlated with emergence of psychopathologies during early adulthood. In this study, we investigated the impact of social defeat stress during mid-adolescence on adult male brain and behavior. Adolescent male Sprague-Dawley rats were exposed to repeated social defeat for five days while controls were placed into a novel empty cage. When exposed to defeat-associated cues as adults, previously defeated rats showed increased risk assessment and behavioral inhibition, demonstrating long-term memory for the defeat context. However, previously defeated rats exhibited increased locomotion in both elevated plus maze and open field tests, suggesting heightened novelty-induced behavior. Adolescent defeat also affected adult monoamine levels in stress-responsive limbic regions, causing decreased medial prefrontal cortex dopamine, increased norepinephrine and serotonin in the ventral dentate gyrus, and decreased norepinephrine in the dorsal raphe. Our results suggest that adolescent social defeat produces both deficits in anxiety responses and altered monoaminergic function in adulthood. This model offers potential for identifying specific mechanisms induced by severe adolescent social stress that may contribute to increased adult male vulnerability to psychopathology.
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影响因子：
3.4
作者：
Forster, Gina L.;Pringle, Ronald B.;Renner, Kenneth J.
通讯作者：
Renner, Kenneth J.
影响因子：
2.9
作者：
Björkqvist, K
通讯作者：
Björkqvist, K
影响因子：
2.9
作者：
Farmer, CJ;Isakson, TR;Renner, KJ
通讯作者：
Renner, KJ
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL
影响因子：
2.9
作者：
Douglas, LA;Varlinskaya, EI;Spear, LP
通讯作者：
Spear, LP