Use it or lose it to age: A review of bone and muscle communication.
Use it or lose it to age: A review of bone and muscle communication.
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DOI：
10.1016/j.bone.2018.11.002
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发表时间：
2019-03
期刊：
影响因子：
4.1
通讯作者：
Bonewald L
中科院分区：
文献类型：
--
作者：
Bonewald L
直到最近，人们还认为肌肉和骨骼之间的唯一相互作用是机械的，肌肉充当滑轮，骨骼充当杠杆来移动生物体。一个相对较新的概念是，肌肉，特别是收缩的肌肉，作为一个分泌器官，调节新陈代谢。一个更新的概念是，骨骼，特别是骨骼中的骨细胞，作为内分泌细胞作用于其他器官，如肾脏和最近的肌肉。这两个新概念逻辑上导致了第三个概念：肌肉和骨骼通过可溶性因子进行交流。通过肌肉因子如肌生长抑制素、鸢尾素和肌肉代谢物β-氨基异丁酸、BAIBA以及通过骨因子如骨钙素、转化生长因子β、TGFβ、前列腺素E2、PGE 2和Wnt发生串扰。其中一些因素对对立组织有积极影响，也有一些消极影响。骨骼和肌肉的一个共同特征是它们的组织都是机械负荷的，并且它们的许多分泌因子都受负荷的调节。这种机械负荷，也被称为运动，对许多系统都有有益的影响，导致肌肉和骨骼因素可能是运动有益影响的假设。许多衰老的特征和与衰老相关的疾病，如肌肉减少症和骨质疏松症，以及神经系统疾病，如阿尔茨海默病和痴呆症，都可以通过运动来延缓。这种有益的效果已被归因于增加血流量增加氧气和营养物质，但也可能是由于肌肉骨骼系统的分泌组概述了这一审查。
Until recently, it was assumed that the only interaction between muscle and bone is mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism. A relatively new concept is that muscle, especially contracted muscle, acts as a secretory organ, regulating metabolism. An even newer concept is that bone, especially the osteocytes in bone, act as endocrine cells targeting other organs such as kidney and more recently, muscle. These two new concepts logically led to the third concept: that muscle and bone communicate via soluble factors. Crosstalk occurs through muscle factors such as myostatin, irisin, and a muscle metabolite, β-aminoisobutyric acid, BAIBA, and through bone factors such as osteocalcin, transforming growth factor beta, TGFβ, Prostaglandin E2, PGE2 and Wnts. Some of these factors have positive and some negative effects on the opposing tissue. One feature both bone and muscle have in common is that their tissues are mechanically loaded and many of their secreted factors are regulated by load. This mechanical loading, also known as exercise, has beneficial effects on many systems leading to the hypothesis that muscle and bone factors can be responsible for the beneficial effects of exercise. Many of the characteristics of aging and diseases associated with aging such as sarcopenia and osteoporosis and neurological conditions such as Alzheimer’s disease and dementia, are delayed by exercise. This beneficial effect has been ascribed to increased blood flow increasing oxygen and nutrients, but could also be due to the secretome of the musculoskeletal system as outlined in this review.
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影响因子：
6.2
作者：
Borsheim, Elisabet;Herndon, David N.;Hawkins, Hal K.;Suman, Oscar E.;Cotter, Matthew;Klein, Gordon L.
通讯作者：
Klein, Gordon L.
影响因子：
8.8
作者：
Dole NS;Mazur CM;Acevedo C;Lopez JP;Monteiro DA;Fowler TW;Gludovatz B;Walsh F;Regan JN;Messina S;Evans DS;Lang TF;Zhang B;Ritchie RO;Mohammad KS;Alliston T
通讯作者：
Alliston T
影响因子：
3.6
作者：
Boot, AM;de Coo, RFM;Keizer-Schrama, SMPFD
通讯作者：
Keizer-Schrama, SMPFD
影响因子：
4.8
作者：
Dallas, SL;Rosser, JL;Bonewald, LF
通讯作者：
Bonewald, LF
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA