Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.
Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.
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DOI：
10.1371/journal.pone.0005224
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Deus J
中科院分区：
文献类型：
--
作者：
Pujol J;López-Solà M;Ortiz H;Vilanova JC;Harrison BJ;Yücel M;Soriano-Mas C;Cardoner N;Deus J
伤害性刺激可能会引起比传统神经影像学部分检测到的刺激持续时间更长的大脑反应。纤维肌痛患者通常会因轻微刺激而感到剧烈疼痛。我们的目的是通过生成根据大脑反应持续时间进行调整的激活图来表征纤维肌痛患者对疼痛压力的大脑反应。对 27 名女性（平均年龄：47.8 岁）进行了功能磁共振成像评估。样本包括 9 名纤维肌痛患者和 9 名健康受试者，他们的拇指受到 4 kg/cm2 的压力。另外九名对照受试者接受了 6.8 kg/cm2 剂量，以匹配患者感知疼痛的严重程度。独立成分分析描述了大脑对压力的实际反应的时间动态。使用获得的时间过程估计统计参数图。所有组的体感区域大脑对压力（18 秒）的反应始终超过刺激应用（9 秒）。遵循这种时间动态的功能磁共振成像图显示，纤维肌痛患者对 4 kg/cm2 的压力有完整的疼痛网络反应（感觉运动皮层、盖岛岛、扣带皮层和基底神经节）。在健康受试者中，对这种低强度压力的反应主要涉及体感皮层。当与感知疼痛（6.8 kg/cm2）匹配时，对照受试者也表现出疼痛相关区域的全面激活，但纤维肌痛患者的前岛叶-基底神经节复合体和扣带皮层表现出明显更大的激活。结果表明，数据驱动的功能磁共振成像评估可以补充传统的神经影像学来表征疼痛反应，并且纤维肌痛患者大脑激活的增强可能与情绪相关区域特别相关。
Nociceptive stimuli may evoke brain responses longer than the stimulus duration often partially detected by conventional neuroimaging. Fibromyalgia patients typically complain of severe pain from gentle stimuli. We aimed to characterize brain response to painful pressure in fibromyalgia patients by generating activation maps adjusted for the duration of brain responses. Twenty-seven women (mean age: 47.8 years) were assessed with fMRI. The sample included nine fibromyalgia patients and nine healthy subjects who received 4 kg/cm2 of pressure on the thumb. Nine additional control subjects received 6.8 kg/cm2 to match the patients for the severity of perceived pain. Independent Component Analysis characterized the temporal dynamics of the actual brain response to pressure. Statistical parametric maps were estimated using the obtained time courses. Brain response to pressure (18 seconds) consistently exceeded the stimulus application (9 seconds) in somatosensory regions in all groups. fMRI maps following such temporal dynamics showed a complete pain network response (sensory-motor cortices, operculo-insula, cingulate cortex, and basal ganglia) to 4 kg/cm2 of pressure in fibromyalgia patients. In healthy subjects, response to this low intensity pressure involved mainly somatosensory cortices. When matched for perceived pain (6.8 kg/cm2), control subjects showed also comprehensive activation of pain-related regions, but fibromyalgia patients showed significantly larger activation in the anterior insula-basal ganglia complex and the cingulate cortex. The results suggest that data-driven fMRI assessments may complement conventional neuroimaging for characterizing pain responses and that enhancement of brain activation in fibromyalgia patients may be particularly relevant in emotion-related regions.
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影响因子：
--
作者：
Giesecke, T;Gracely, RH;Clauw, DJ
通讯作者：
Clauw, DJ
影响因子：
2.5
作者：
Calhoun, VD;Adali, T;Pekar, JJ
通讯作者：
Pekar, JJ
DOI：
10.1176/appi.neuropsych.19.3.274
发表时间：
2007-06-01
影响因子：
2.9
作者：
Anand, Amit;Li, Yu;Lowe, Mark J.
通讯作者：
Lowe, Mark J.
影响因子：
5.7
作者：
McKeown, MJ
通讯作者：
McKeown, MJ
影响因子：
4.8
作者：
Li, Yi-Ou;Adali, Tuelay;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.