Dynamic functional network reconfiguration underlying the pathophysiology of schizophrenia and autism spectrum disorder.
Dynamic functional network reconfiguration underlying the pathophysiology of schizophrenia and autism spectrum disorder.
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DOI：
10.1002/hbm.25205
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发表时间：
2021-01
影响因子：
4.8
通讯作者：
Calhoun VD
中科院分区：
文献类型：
--
作者：
Fu Z;Sui J;Turner JA;Du Y;Assaf M;Pearlson GD;Calhoun VD
人类大脑的动态跨越多个空间尺度，从与特定区域/网络相关的连接到全球组织，每个空间尺度代表不同的大脑机制。然而，在不同的空间尺度上的大脑重构很少被探索，它们是否与大脑疾病的神经方面有关还远未被理解。在这项研究中，我们引入了一种称为逐步功能网络重构（SFNR）的动态测量方法来表征大脑配置在不同空间尺度上的重新连接。我们将sFNR应用于两个独立的数据集，一个包括160名健康对照（HC）和151名精神分裂症（SZ）患者，另一个包括314名HC和255名自闭症谱系障碍（ASD）患者。我们发现SZ和ASD都增加了全脑sFNR和小脑和皮质下/感觉运动域之间的sFNR。在ICN水平上，SZ的异常主要位于皮质下、感觉和小脑区域内的ICN，而ASD的异常在各区域之间更为广泛。有趣的是，sFNR中小脑和感觉运动域之间的重叠SZ-ASD异常与SZ的推理-问题解决表现（r =-0.1652，p = 0.0058）以及ASD的自闭症诊断观察表（r = 0.1853，p = 0.0077）相关。我们的研究结果表明，动态重构赤字可能是一个关键的交叉点SZ和ASD。在不同空间尺度上对脑动力学的研究可以为功能重构提供全面的见解，这可能会促进我们对认知下降和脑疾病的其他病理生理学的认识。在这项研究中，我们发现精神分裂症和自闭症都增加了全脑动态网络重构，并增加了与小脑和皮层下/感觉运动域相关的动态网络重构。有趣的是，这些疾病在小脑和感觉运动域之间的动态网络重构中的重叠异常与精神分裂症的推理问题解决表现以及自闭症诊断观察表相关。我们的研究结果表明，动态功能连接缺陷可能是精神分裂症和自闭症的一个关键交叉点。
The dynamics of the human brain span multiple spatial scales, from connectivity associated with a specific region/network to the global organization, each representing different brain mechanisms. Yet brain reconfigurations at different spatial scales are seldom explored and whether they are associated with the neural aspects of brain disorders is far from understood. In this study, we introduced a dynamic measure called step‐wise functional network reconfiguration (sFNR) to characterize how brain configuration rewires at different spatial scales. We applied sFNR to two independent datasets, one includes 160 healthy controls (HCs) and 151 patients with schizophrenia (SZ) and the other one includes 314 HCs and 255 individuals with autism spectrum disorder (ASD). We found that both SZ and ASD have increased whole‐brain sFNR and sFNR between cerebellar and subcortical/sensorimotor domains. At the ICN level, the abnormalities in SZ are mainly located in ICNs within subcortical, sensory, and cerebellar domains, while the abnormalities in ASD are more widespread across domains. Interestingly, the overlap SZ‐ASD abnormality in sFNR between cerebellar and sensorimotor domains was correlated with the reasoning‐problem‐solving performance in SZ (r = −.1652, p = .0058) as well as the Autism Diagnostic Observation Schedule in ASD (r = .1853, p = .0077). Our findings suggest that dynamic reconfiguration deficits may represent a key intersecting point for SZ and ASD. The investigation of brain dynamics at different spatial scales can provide comprehensive insights into the functional reconfiguration, which might advance our knowledge of cognitive decline and other pathophysiology in brain disorders. In this study, we found that both schizophrenia and autism have increased whole‐brain dynamic network reconfiguration and increased dynamic network reconfiguration associated with cerebellar and subcortical/sensorimotor domains. Interestingly, the diseases' overlapping abnormality in dynamic network reconfiguration between cerebellar and sensorimotor domains was correlated with the reasoning‐problem‐solving performance in schizophrenia as well as the Autism Diagnostic Observation Schedule in autism. Our findings suggest that dynamic functional connectivity deficits may represent a key intersecting point for schizophrenia and autism.
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影响因子：
16.2
作者：
Dinstein I;Heeger DJ;Lorenzi L;Minshew NJ;Malach R;Behrmann M
通讯作者：
Behrmann M
影响因子：
5.7
作者：
Bassett, Danielle S.;Nelson, Brent G.;Mueller, Bryon A.;Camchong, Jazmin;Lim, Kelvin O.
通讯作者：
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DOI：
10.1016/j.nicl.2020.102375
发表时间：
2020
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Du Y;Fu Z;Sui J;Gao S;Xing Y;Lin D;Salman M;Abrol A;Rahaman MA;Chen J;Hong LE;Kochunov P;Osuch EA;Calhoun VD;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
神经影像学中脑部疾病的单受试者预测：前景和陷阱
影响因子：
5.7
作者：
Arbabshirani MR;Plis S;Sui J;Calhoun VD
通讯作者：
Calhoun VD
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM