Unreliable evoked responses in autism.
Unreliable evoked responses in autism.
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DOI：
10.1016/j.neuron.2012.07.026
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发表时间：
2012-09-20
期刊：
影响因子：
16.2
通讯作者：
Behrmann M
中科院分区：
文献类型：
--
作者：
Dinstein I;Heeger DJ;Lorenzi L;Minshew NJ;Malach R;Behrmann M
自闭症被描述为一种一般性神经处理障碍，但在自闭症中可能异常的特定处理特征大多仍不明确。在此，我们提出了此类特征之一的证据：诱发反应可靠性差。我们比较了高功能自闭症个体和对照组在视觉、听觉和躯体感觉皮层的皮层反应幅度和可靠性（各次试验之间的一致性）。各组之间的平均反应幅度在统计学上无差异，但自闭症患者每次试验的反应可靠性明显较弱，导致所有感觉系统的信噪比更小。反应可靠性差异仅在诱发的皮层反应中明显，而在持续的静息状态活动中不明显。这些发现表明，即使对基本的非社会性感觉刺激，异常不可靠的皮层反应也可能代表自闭症中神经处理的一种基本生理改变。研究结果促使自闭症研究进行关键的拓展，以确定自闭症中诸如可靠性、可塑性以及适应/习惯化等基本神经处理特性是否（以及如何）发生改变。
Autism has been described as a disorder of general neural processing, but the particular processing characteristics that might be abnormal in autism have mostly remained obscure. Here, we present evidence of one such characteristic: poor evoked response reliability. We compared cortical response amplitude and reliability (consistency across trials) in visual, auditory, and somatosensory cortices of high-functioning individuals with autism and controls. Mean response amplitudes were statistically indistinguishable across groups, yet trial-by-trial response reliability was significantly weaker in autism, yielding smaller signal-to-noise ratios in all sensory systems. Response reliability differences were evident only in evoked cortical responses and not in ongoing resting-state activity. These findings reveal that abnormally unreliable cortical responses, even to elementary non-social sensory stimuli, may represent a fundamental physiological alteration of neural processing in autism. The results motivate a critical expansion of autism research to determine whether (and how) basic neural processing properties such as reliability, plasticity, and adaptation/habituation are altered in autism.
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