A chromosomally integrated bacteriophage in invasive meningococci.
A chromosomally integrated bacteriophage in invasive meningococci.
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DOI：
10.1084/jem.20050112
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发表时间：
2005-06-20
期刊：
影响因子：
--
通讯作者：
Tinsley CR
中科院分区：
文献类型：
--
作者：
Bille E;Zahar JR;Perrin A;Morelle S;Kriz P;Jolley KA;Maiden MC;Dervin C;Nassif X;Tinsley CR
脑脊髓膜炎是一种可怕的疾病，可以在几个小时内导致以前健康的人死亡。特别地，病原体脑膜炎奈瑟氏菌是人鼻咽的常见居民，因此可以被认为是正常的口腔生物。只有在一小部分殖民者中，细菌会侵入血液，从那里它们可以穿过血脑屏障引起脑膜炎。此外，大多数脑膜炎球菌病是由细菌引起的，这些细菌只属于构成这种遗传可变生物体的种群结构的大量细菌中的少数系统发育组。然而，致病潜力差异的遗传基础仍然难以捉摸。通过对大量确定致病潜力的脑膜炎球菌分离株进行全基因组比较，我们揭示了致病细菌中存在的脑膜炎球菌前噬菌体。丝状家族的噬菌体从染色体上切除，并通过IV型菌毛蛋白分泌素从细菌中分泌。因此，该因子通过在种群中的传播，可能促进新的流行克隆的产生。脑膜炎能够破坏与人类的正常亲密关系并导致侵袭性疾病。
Cerebrospinal meningitis is a feared disease that can cause the death of a previously healthy individual within hours. Paradoxically, the causative agent, Neisseria meningitidis, is a common inhabitant of the human nasopharynx, and as such, may be considered a normal, commensal organism. Only in a small proportion of colonized people do the bacteria invade the bloodstream, from where they can cross the blood–brain barrier to cause meningitis. Furthermore, most meningococcal disease is caused by bacteria belonging to only a few of the phylogenetic groups among the large number that constitute the population structure of this genetically variable organism. However, the genetic basis for the differences in pathogenic potential remains elusive. By performing whole genome comparisons of a large collection of meningococcal isolates of defined pathogenic potential we brought to light a meningococcal prophage present in disease-causing bacteria. The phage, of the filamentous family, excises from the chromosome and is secreted from the bacteria via the type IV pilin secretin. Therefore, this element, by spreading among the population, may promote the development of new epidemic clones of N. meningitidis that are capable of breaking the normal commensal relationship with humans and causing invasive disease.
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影响因子：
3.1
作者：
Klee, SR;Nassif, X;Tinsley, CR
通讯作者：
Tinsley, CR
DOI：
10.1084/jem.129.6.1307
发表时间：
1969-06-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Goldschneider I;Gotschlich EC;Artenstein MS
通讯作者：
Artenstein MS
影响因子：
36.8
作者：
DENSEN, P
通讯作者：
DENSEN, P
影响因子：
3.7
作者：
MAZUR, BJ;ZINDER, ND
通讯作者：
ZINDER, ND
影响因子：
5.6
作者：
Rakonjac, J;Model, P
通讯作者：
Model, P