Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development.
Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development.
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DOI：
10.1016/j.bbmt.2012.03.005
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发表时间：
2012-06
影响因子：
4.3
通讯作者：
Sarantopoulos, Stefanie
中科院分区：
文献类型：
--
作者：
Fedoriw, Yuri;Samulski, T. Danielle;Deal, Allison M.;Dunphy, Cherie H.;Sharf, Andrew;Shea, Thomas C.;Serody, Jonathan S.;Sarantopoulos, Stefanie
Patients without chronic graft-versus-host disease (cGVHD) have robust B cell reconstitution and are able to maintain B cell homeostasis after allogeneic hematopoietic stem cell transplantation (HSCT). To determine whether B lymphopoiesis differs before cGVHD develops, we examined bone marrow (BM) biopsies for terminal deoxynucleotidyl transferase (TdT) and PAX5 immunostaining early post-HSCTat day 30 when all patients have been shown to have high B cell activating factor (BAFF) levels. We found significantly greater numbers of BM B cell precursors in patients who did not develop cGVHD compared with those who developed cGVHD (median = 44 vs 2 cells/high powered field [hpf]; respectively; P < .001). Importantly, a significant increase in precursor B cells was maintained when patients receiving high-dose steroid therapy were excluded (median = 49 vs 20 cells/hpf; P =.017). Thus, we demonstrate the association of BM B cell production capacity in human GVHD development. Increased BM precursor B cell number may serve to predict good clinical outcome after HSCT.
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影响因子：
4.3
作者：
Greinix, Hildegard T.;Pohlreich, David;Pickl, Winfried F.
通讯作者：
Pickl, Winfried F.
影响因子：
32.4
作者：
Thien, M;Phan, TG;Brink, R
通讯作者：
Brink, R
影响因子：
20.3
作者：
Storek, J;Espino, G;Maloney, D
通讯作者：
Maloney, D
DOI：
10.3324/haematol.2011.041814
发表时间：
2011-09-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
van Dorp, Suzanne;Resemann, Henrike;Kuball, Jurgen
通讯作者：
Kuball, Jurgen
影响因子：
4.8
作者：
Carlens, S;Ringdén, O;Aschan, J
通讯作者：
Aschan, J