AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study.
AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study.
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DOI：
10.1186/s12944-018-0920-4
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发表时间：
2018-12-03
影响因子：
4.5
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Liu Y;Zhao P;Cheng M;Yu L;Cheng Z;Fan L;Chen C
以往的研究表明，甘油三酯与高密度脂蛋白胆固醇的比值(下称甘油三酯/高密度脂蛋白胆固醇)是心血管疾病、胰岛素抵抗和代谢综合征的主要危险因素之一。然而，天冬氨酸氨基转移酶(AST)/丙氨酸氨基转移酶(ALT)比值与臂踝脉搏波传导速度(BaPWV)的相关性研究较少。本研究旨在探讨日本人群中谷草转氨酶/丙氨酸氨基转移酶比值与臂踝脉搏波速度的关系。本研究是一项横断面研究。共有646名年龄在24-84 的日本非脂肪肝男性和女性在日本的一家健康检查中心接受了健康体检计划，其中包括BaPWV检查结果和各种标准化问卷。主要观察指标包括AST/ALT比值、baPWV、脂肪肝和绝经后状态。腹部超声诊断脂肪肝。绝经后状态被定义为月经停止后1 年开始。在调整了可能的混杂因素(年龄、性别、BMI、SBP、DBP、AST、ALT、GGT、尿酸、空腹血糖、TC、LDL、EGFR、吸烟和运动状态、脂肪肝、饮酒和ABI)后，AST/ALT与baPWV之间存在非线性关系，拐点为5.6。拐点左右两侧的效应大小和可信区间分别为12.7(1.9~2 3.5)和 − 16.7(− 36.8~3.3)。对饮酒量超过2 80 g/周的受试者的亚组分析显示，AST/ALT与BaPWV呈负相关(β = − 30.7，95%CI(− 5 3.1，− 8.4))，交互作用的P值<0.0 5。AST/ALT与baPWV呈非线性关系。当AST/ALT<5.6时，AST/ALT与baPWV呈正相关。此外，在过量饮酒的受试者中，这一趋势正好相反。
Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio (henceforth TG/HDL-C) is one of the major risk factors for cardiovascular disease, insulin resistance and metabolism syndrome. However, there are fewer investigations of the correlations between the aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio and brachial ankle pulse wave velocity (baPWV). This study was undertaken to investigate the relationship between the AST to ALT ratio and brachial-ankle pulse wave velocity (baPWV) in a Japanese population. The present study was a cross-sectional study. A total of 646 Japanese men and women without fatty liver, aged 24—84 years old, received a health medical check-up programme including the results from baPWV inspection and various standardized questionnaires in a health examination centre in Japan. Main outcome measures included AST/ALT ratio, baPWV, fatty liver and postmenopausal status. Abdominal ultrasonography was used to diagnose fatty liver. A postmenopausal state was defined as beginning 1 year following the cessation of menses. After adjusting for potential confounders (age, sex, BMI, SBP, DBP, AST, ALT, GGT, uric acid, fasting glucose, TC, LDL, eGFR, smoking and exercise statuses, fatty liver, alcohol consumption and ABI), a non-linear relationship was detected between AST/ALT and baPWV, which had an inflection point of 5.6. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 12.7 (1.9 to 23.5) and − 16.7 (− 36.8 to 3.3), respectively. Subgroup analysis in participants with excessive alcohol consumption (more than 280 g/week) showed that AST/ALT had a negative correlation with baPWV (β = − 30.7, 95%CI (− 53.1, − 8.4)), and the P value for the interaction was less than 0.05. The relationship between AST/ALT and baPWV is non-linear. AST/ALT was positively correlated with baPWV when AST/ALT was less than 5.6. In addition, the trend was the opposite in subjects who consumed excessive amounts of alcohol.
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