Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.
Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.
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DOI：
10.1136/bmjopen-2014-005413
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发表时间：
2014-10-03
期刊：
影响因子：
2.9
通讯作者：
Fukui M
中科院分区：
文献类型：
--
作者：
Fukuda T;Hamaguchi M;Kojima T;Ohshima Y;Ohbora A;Kato T;Nakamura N;Fukui M
本研究旨在探讨日本男性和女性血清γ谷氨酰转肽酶(GGT)与臂踝脉搏波速度(BPWV)之间的关系，以此作为日本男性和女性动脉粥样硬化的指标。一项横断面研究。日本的一家健康检查中心。912名年龄在24-84 的日本男性和女性从接受了健康检查计划的人中招募，这些人使用了标准化的问卷和自动波形分析仪来测量BaPWV。测定血清GGT浓度和baPWV。脂肪肝的诊断采用腹部超声的标准化标准。绝经后状态定义为月经停止后1 年开始。在女性中，Log2GGT与BaPWV呈正相关(β=0.11，95%CI0.02~0.19，p<；0.05)，与年龄、体重指数、收缩压、空腹血糖、甘油三酯、估计肾小球滤过率、脂肪肝、绝经状态和生活方式参数无关。然而，在男性中，Log2GGT与BaPWV的正相关关系在多变量线性回归分析中并不显著(β=−0.04，95%CI−0.10~0.03，p=0.28)。血清GGT水平与baPWV相关，与包括脂肪肝或绝经状态在内的协变量无关，仅在女性，而在男性没有。
The purpose of this study was to determine the relationship between serum γ-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for fatty liver. A cross-sectional study. A health check-up centre in Japan. 912 Japanese men and women aged 24–84 years recruited from people who received a medical health check-up programme with a standardised questionnaire and an automatic waveform analyser to measure baPWV. We measured serum GGT concentrations and baPWV. Fatty liver was diagnosed by standardised criteria using abdominal ultrasonography. The postmenopausal state was defined as beginning 1 year after the cessation of menses. In women, log2 GGT was positively associated with baPWV (β=0.11, 95% CI 0.02 to 0.19, p<0.05), independent of age, body mass index, systolic blood pressure, fasting plasma glucose, triglycerides, estimated glomerular filtration rate, fatty liver, menopausal state and parameters of lifestyles. However, in men, the positive association of log2 GGT with baPWV was not significant (β=−0.04, 95% CI −0.10 to 0.03, p=0.28) in multivariable linear regression analyses. The serum GGT level was associated with baPWV, independently of covariates including fatty liver or menopausal state just in women, but not in men.
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DOI：
10.1016/j.jceh.2012.10.004
发表时间：
2013-03-01
影响因子：
3
作者：
Loomba R;Doycheva I;Bettencourt R;Cohen B;Wassel CL;Brenner D;Barrett-Connor E
通讯作者：
Barrett-Connor E
影响因子：
9.8
作者：
Gunji, Toshiaki;Matsuhashi, Nobuyuki;Urabe, Akio
通讯作者：
Urabe, Akio
影响因子：
3.3
作者：
Motobe, K;Tomiyama, H;Yamashina, A
通讯作者：
Yamashina, A
影响因子：
7.8
作者：
Borrás, C;Gambini, J;Viña, J
通讯作者：
Viña, J
影响因子：
3.2
作者：
McKenzie, Joyce;Fisher, B. Miles;Sattar, Naveed
通讯作者：
Sattar, Naveed