How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model.
How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model.
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DOI：
10.1038/jid.2015.4
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发表时间：
2015-05
影响因子：
6.5
通讯作者：
Nghiem, Paul
中科院分区：
文献类型：
--
作者：
Church, Candice D.;Nghiem, Paul
The Merkel cell polyomavirus (MCPyV), discovered in 2008, drives development of most Merkel cell carcinomas (MCCs) through several canonical mechanisms. A glaring gap in our knowledge remains the basis by which MCPyV, among all 12 human polyomaviruses, is the only one that causes cancer in humans. Moreover, initial attempts by numerous groups have failed to reproduce MCC in mice using oncoproteins from this polyomavirus. Verhaegen at al. report MCPyV small T antigen-expressing transgenic mice that now provide insight into in vivo transformation mechanisms.
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