Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why.
Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why.
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DOI：
10.1016/j.fertnstert.2017.05.031
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发表时间：
2017-07
影响因子：
6.7
通讯作者：
Kim JJ
中科院分区：
文献类型：
--
作者：
Lessey BA;Kim JJ
子宫内膜维持着对增殖和凋亡的复杂控制，作为重复月经周期的一部分，为子宫内膜着床和妊娠做好了准备。着床和月经都依赖于炎症机制，在子宫内膜异位症的背景下，为慢性炎症的建立创造了机会，慢性炎症破坏子宫内膜容受性，导致不孕和异常出血。临床上，毫无疑问，子宫内膜异位症患者的子宫内膜对胚胎着床的接受能力较差，并且有强有力的证据表明，子宫内膜改变与该疾病导致的周期生育能力下降有关。在这里，我们提供了关于这些变化的统一概念，以及它们如何通过异常的细胞信号通路和减少子宫内膜异位症女性异位子宫内膜中关键稳态蛋白的表达来协调促进孕酮抵抗和雌激素优势。
The endometrium maintains complex controls on proliferation and apoptosis as part of repetitive menstrual cycles that prepare the endometrium for the window of implantation and pregnancy. The reliance on inflammatory mechanisms for both implantation and menstruation, creates the opportunity in the setting of endometriosis for the establishment of chronic inflammation that is disruptive to endometrial receptivity, causing both infertility and abnormal bleeding. Clinically, there can be little doubt that the endometrium of women with endometriosis is less receptive to embryo implantation, and strong evidence exists to suggests that endometrial changes are associated with decreased cycle fecundity as a result of this disease. Here we provide unifying concepts regarding those changes and how they are coordinated to promote progesterone resistance and estrogen dominance through aberrant cell signaling pathways and reduced expression of key homeostatic proteins in eutopic endometrium of women with endometriosis.
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影响因子：
2.5
作者：
Ahn JI;Yoo JY;Kim TH;Kim YI;Ferguson SD;Fazleabas AT;Young SL;Lessey BA;Ahn JY;Lim JM;Jeong JW
通讯作者：
Jeong JW
影响因子：
6.7
作者：
Attar, Erkut;Bulun, Serdar E.
通讯作者：
Bulun, Serdar E.
影响因子：
4.8
作者：
Asada, Sachie;Daitoku, Hiroaki;Fukamizu, Akiyoshi
通讯作者：
Fukamizu, Akiyoshi
影响因子：
5
作者：
BOUTTEN, A;DEHOUX, M;DURAND, G
通讯作者：
DURAND, G
DOI：
10.4049/jimmunol.1501138
发表时间：
2015-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ahn SH;Edwards AK;Singh SS;Young SL;Lessey BA;Tayade C
通讯作者：
Tayade C