Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia.
Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia.
复制标题
严重肢体缺血患者肌内 phVEGF165 基因转移后慢性缺血性神经病变的改善。
作者：
D. Simovic;J. Isner;A. Ropper;A. Pieczek;D. H. Weinberg
客观的
OBJECTIVE
To investigate the effects of vascular endothelial growth factor gene therapy on ischemic neuropathy in patients with critical limb ischemia.
DESIGN
An open-label, dose-escalating trial. Patients with angiographically proven critical leg ischemia received injections of phVEGF(165) human plasmid in the muscles of the ischemic limb. Testing before treatment and at 3 and 6 months included (1) symptom severity score, (2) clinical examination score, and (3) electrophysiologic studies. Clinical and electrophysiologic examiners were masked to each other's findings.
SETTING
A tertiary care referral hospital and a major teaching affiliate of Tufts University School of Medicine, Boston, Mass.
RESULTS
Of 29 consecutive patients enrolled, 17 (19 limbs) completed the 6 months of study. Six patients had diabetes. Compared with baseline studies, treated patients had significant clinical improvements in the symptom score (P<.01), sensory examination score (P<.01), total examination score (P =.01), peroneal motor amplitude (P =.03), and quantitative vibration threshold (P =.04). Improvement in the vascular ankle-brachial index in treated legs (P<.01) corresponded to improvement in neuropathy in the same limb. Neurologic improvement was seen in 4 of 6 patients with diabetes who completed the study. No clinical, electrophysiologic, or vascular improvements were observed in untreated legs.
CONCLUSIONS
Ischemic neuropathy might be a reversible condition, and therapeutic angiogenesis might be an effective treatment. The presence of diabetes does not preclude a response to this therapy.
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影响因子：
15.9
作者：
Murohara, T;Asahara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
37.8
作者：
Rivard, A;Fabre, JE;Isner, JM
通讯作者：
Isner, JM
在兔下肢血管功能不全模型中给予血管内皮生长因子后侧支动脉细胞增殖增加的时间过程。
DOI：
--
发表时间：
1995
期刊：
The American journal of pathology.
影响因子：
--
作者：
Takeshita,S;Rossow,ST;Kearney,M;Zheng,LP;Bauters,C;Bunting,S;Ferrara,N;Symes,JF;Isner,JM
通讯作者：
Isner,JM
影响因子：
37.8
作者：
Y. Tsurumi;S. Takeshita;Dongfen Chen;M. Kearney;S. Rossow;J. Passeri;J. Horowitz;J. Symes;J. Isner
通讯作者：
Y. Tsurumi;S. Takeshita;Dongfen Chen;M. Kearney;S. Rossow;J. Passeri;J. Horowitz;J. Symes;J. Isner
影响因子：
15.9
作者：
TAKESHITA, S;ZHENG, LP;ISNER, JM
通讯作者：
ISNER, JM