Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa.
Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa.
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DOI：
10.1002/jbmr.1640
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发表时间：
2012-09
影响因子：
6.2
通讯作者：
Klibanski, Anne
中科院分区：
文献类型：
--
作者：
Fazeli, Pouneh K.;Bredella, Miriam A.;Freedman, Lauren;Thomas, Bijoy J.;Breggia, Anne;Meenaghan, Erinne;Rosen, Clifford J.;Klibanski, Anne
患有神经性厌食症（AN）的女性尽管内脏和皮下脂肪储备较低，但骨髓脂肪量升高，这与骨矿物质密度（BMD）呈负相关。目前尚不清楚骨髓脂肪量是否随着AN的恢复而持续升高或降低。在这项研究中，我们调查了骨髓脂肪的变化与AN的恢复和前脂肪细胞因子（Pref）-1 -EGF样蛋白质家族的成员和脂肪细胞和成骨细胞分化的调节剂-和脂肪库和BMD之间的关系，与AN和健康对照（HC）的女性相比，从AN（AN-R）恢复的女性。我们研究了29名女性：14名活动性或恢复性AN患者（30.7 ± 2.2年（平均值± SEM））和15名正常体重对照者（27.8 ± 1.2年）。我们通过1H-磁共振波谱测量L4椎骨和股骨的骨髓脂肪组织（MAT），通过DXA测量脊柱、髋部和全身的BMD，以及血清Pref-1和瘦素水平。我们发现AN-R中L4椎骨的MAT显著低于AN（p = 0.03），与HC中的水平相当。与AN相比，AN-R中的Pref-1水平也显著较低（p = 0.02），并且与健康对照中的水平相当。尽管Pref-1与AN患者L4椎体MAT呈正相关（R = 0.94; p = 0.002），但我们发现其与HC患者L4椎体MAT呈负相关（R =-0.71; p = 0.004）。因此，我们已经证明MAT和Pref-1水平随着AN的恢复而降低。我们的数据表明，Pref-1可能有不同的影响，在营养缺乏的状态相比，营养充足。
Women with anorexia nervosa (AN) have elevated marrow fat mass despite low visceral and subcutaneous fat depots, which is inversely associated with bone mineral density (BMD). Whether marrow fat mass remains persistently elevated or decreases with recovery from AN is currently unknown. In this study, we investigated changes in marrow fat with recovery from AN and the relationship between preadipocyte factor (Pref)-1 -- a member of the EGF-like family of proteins and regulator of adipocyte and osteoblast differentiation -- and fat depots and BMD in women who have recovered from AN (AN-R) compared to women with AN and healthy controls (HC). We studied 29 women: 14 with active or recovered AN (30.7 + 2.2 years (mean ± SEM)) and 15 normal-weight controls (27.8 ± 1.2 years). We measured marrow adipose tissue (MAT) of the L4 vertebra and femur by 1H-magnetic resonance spectroscopy, BMD of the spine, hip and total body by DXA and serum Pref-1 and leptin levels. We found that MAT of the L4 vertebra was significantly lower in AN-R as compared to AN (p = 0.03) and was comparable to levels in HC. Pref-1 levels were also significantly lower in AN-R as compared to AN (p = 0.02) and comparable to levels in healthy controls. Although Pref-1 was positively associated with MAT of the L4 vertebra in AN (R = 0.94; p = 0.002), we found that it was inversely associated with MAT of the L4 vertebra in HC (R = −0.71; p = 0.004). Therefore, we have demonstrated that MAT and Pref-1 levels decrease with recovery from AN. Our data suggest that Pref-1 may have differential effects in states of nutritional deprivation as compared to nutritional sufficiency.
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DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
影响因子：
4.1
作者：
Post, S.;Abdallah, B. M.;Kassem, M.
通讯作者：
Kassem, M.
影响因子：
5.8
作者：
Soyka, LA;Grinspoon, S;Klibanski, A
通讯作者：
Klibanski, A
影响因子：
5.8
作者：
Grinspoon, S;Baum, H;Klibanski, A
通讯作者：
Klibanski, A
影响因子：
2.6
作者：
Barthe, N;Braillon, P;BasseCathalinat, B
通讯作者：
BasseCathalinat, B