Carbon Ion irradiation in the treatment of grossly incomplete or unresectable malignant peripheral nerve sheaths tumors: acute toxicity and preliminary outcome.
Carbon Ion irradiation in the treatment of grossly incomplete or unresectable malignant peripheral nerve sheaths tumors: acute toxicity and preliminary outcome.
复制标题
DOI：
10.1186/s13014-015-0414-8
复制
发表时间：
2015-05-06
期刊：
影响因子：
--
通讯作者：
Roeder F
中科院分区：
文献类型：
--
作者：
Jensen AD;Uhl M;Chaudhri N;Herfarth KK;Debus J;Roeder F
报告我们早期应用碳离子照射治疗大体残留或不能切除的恶性周围神经鞘瘤（MPNST）的经验。我们回顾性分析了2010年至2013年期间在我们机构接受碳离子照射（C12）治疗的11例MPNST患者（患者）。所有患者在放射治疗开始时均有可测量的大体病变。中位年龄为47岁（29-79岁）。肿瘤主要位于骨盆/骶骨（5例）和鼻窦/眼眶区域（5例）。5例患者已出现复发情况，3例患者既往接受过放疗，3例MPNST与1型神经纤维瘤病（NF 1）相关。中位累积剂量为60 GyE。以IMRT加C12加强（4名患者）或仅C12（7名患者）的组合进行治疗。中位随访时间为17个月（3-31个月）。我们观察到3例局部进展，估计1年和2年局部控制率为65%。1例患者发生远处转移失败，估计1年和2年PFS率为56%。2例患者死亡，因此估计的1年和2年OS率为75%。急性放射相关毒性一般较轻，未观察到3级副作用。2例患者出现重度晚期毒性（3级）（牙关紧闭、伤口愈合延迟）。碳离子照射产生非常有前途的短期局部控制和总体生存率与低发病率的患者患有严重残留或不可切除的恶性周围神经鞘肿瘤，并应进一步研究在前瞻性试验。
To report our early experience with carbon ion irradiation in the treatment of gross residual or unresectable malignant peripheral nerve sheath tumors (MPNST). We retrospectively analysed 11 patients (pts) with MPNST, who have been treated with carbon ion irradiation (C12) at our institution between 2010 and 2013. All pts had measurable gross disease at the initiation of radiation treatment. Median age was 47 years (29-79). Tumors were mainly located in the pelvic/sacral (5 pts) and sinunasal/orbital region (5 pts). 5 pts presented already in recurrent situation, 3 pts had been previously irradiated, and in 3 pts MPNST were neurofibromatosis type 1 (NF1) associated. Median cumulative dose was 60 GyE. Treatment was carried out either as a combination of IMRT plus C12 boost (4 pts) or C12 only (7 pts). Median follow-up was 17 months (3-31 months). We observed 3 local progressions, translating into estimated 1- and 2-year local control rates of 65%. One patient developed distant failure, resulting in estimated 1- and 2-year PFS rates of 56%. Two patients have died, therefore the estimated 1- and 2-year OS rates are 75%. Acute radiation related toxicities were generally mild, no grade 3 side effects were observed. Severe late toxicity (grade 3) was scored in 2 patients (trismus, wound healing delays). Carbon ion irradiation yields very promising short term local control and overall survival rates with low morbidity in patients suffering from gross residual or unresectable malignant peripheral nerve sheath tumors and should be further investigated in a prospective trial.
登录
查看更多内容
影响因子：
--
作者：
Hu, K S;Harrison, L C
通讯作者：
Harrison, L C
DOI：
10.1016/0360-3016(95)00111-b
发表时间：
1995-07-15
影响因子：
7
作者：
MUNDT, AJ;AWAN, A;WEICHSELBAUM, RR
通讯作者：
WEICHSELBAUM, RR
影响因子：
6.2
作者：
Anghileri, Matteo;Miceli, Rosalba;Gronchi, Alessandro
通讯作者：
Gronchi, Alessandro
影响因子：
45.3
作者：
Carli, M;Ferrari, A;Treuner, J
通讯作者：
Treuner, J
影响因子：
3.8
作者：
Roeder, Falk;Goetz, Joerg-Michael;Debus, Juergen
通讯作者：
Debus, Juergen