The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease.
The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease.
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DOI：
10.1136/bmjopen-2012-001893
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发表时间：
2012
期刊：
影响因子：
2.9
通讯作者：
Ritchie K
中科院分区：
文献类型：
--
作者：
Ritchie CW;Ritchie K
流行病学研究表明，针对多种中年危险因素，可以显著降低阿尔茨海默病（AD）的发病率。然而，由于痴呆症不太可能在几十年内被诊断出来，因此需要进行短期结果测量。AD生物标志物的变化先于临床症状多年，但其对中年变化的敏感性仍然未知。PREVENT是一项前瞻性队列研究，在至少150名遗传上具有迟发性AD高、中或低风险的个体中检查中年时的生物标志物状态。参与者是根据父母临床状态和ApoE基因型被分配到高、中、低风险组的患有或未患有AD的个体的子女。2年内检查的生物标志物包括血浆和CSF Aβ42淀粉样蛋白、Tau和pTau、促炎细胞因子、急性期蛋白、内侧颞叶萎缩、白色病变体积、与经鼻和海马功能相关的认知能力以及下丘脑-垂体-肾上腺和交感神经轴调节。 经参与者的全科医生许可，将检测到的病理情况告知他们。基因型的风险状态将不会被揭示。该研究的结果将发表在同行评审的期刊上，并验证用于构建随机对照干预研究的生物标志物。
Epidemiological studies indicate that significant decreases in the incidence of Alzheimer's disease (AD) may be obtained by targeting multiple middle-age risk factors. However, as dementia is unlikely to be diagnosed for decades, short-term outcome measures are required. AD biomarker changes precede clinical symptoms by many years, but their sensitivity to mid-life change remains unknown. PREVENT is a prospective cohort study examining biomarker status at mid-life in at least 150 individuals genetically at high, medium or low risk of late-onset AD. Participants are children of individuals with or without a diagnosed AD allocated to high, medium and low-risk groups according to parental clinical status and ApoE genotype. The biomarkers examined over 2 years are plasma and CSF Aβ42 amyloid, Tau and pTau, proinflammatory cytokines, acute-phase proteins, medial temporal-lobe atrophy, white matter lesion volume, cognitive performance related to transentorhinal and hippocampal functioning and hypothalamic−pituitary−adrenal and sympathetic axes regulation. Detected pathologies are communicated to the participant's general practitioner with their permission. Risk status by genotype would not be revealed. The results of the study would be published in peer-reviewed journals and validated biomarkers used to construct a randomised controlled intervention study.
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