Early-Life Mebendazole Exposure Increases the Risk of Adult-Onset Ulcerative Colitis: A Population-Based Cohort Study.
Early-Life Mebendazole Exposure Increases the Risk of Adult-Onset Ulcerative Colitis: A Population-Based Cohort Study.
复制标题
DOI：
10.14309/ajg.0000000000001933
复制
发表时间：
2022-12-01
影响因子：
9.8
通讯作者：
Jess, Tine
中科院分区：
文献类型：
--
作者：
Agrawal, Manasi;Allin, Kristine H. H.;Iversen, Aske T. T.;Mehandru, Saurabh;Colombel, Jean-Frederic;Jess, Tine
根据卫生假说，接触寄生虫可以预防炎症性肠病（IBD）。我们的目的是研究儿童期接触甲苯咪唑（一种广谱驱虫剂）后IBD的风险。我们使用前瞻性收集的1995年至2018年期间出生在丹麦的所有个体的历史数据进行了一项基于人群的队列研究。我们确定了甲苯咪唑暴露在年龄<18岁，以及在生命早期（<5岁）。我们进行了调整后的考克斯比例风险回归分析，以确定在调整潜在混杂因素后，甲苯咪唑暴露与IBD、溃疡性结肠炎（UC）和克罗恩病（CD）的风险。在队列中的1，520，290人中，有615，794人在儿童或青少年时期接触过甲苯咪唑。随后分别有1，555和1，499人被诊断为儿童和成人发病IBD。在多变量分析中，<18岁的甲苯咪唑暴露不会影响儿童或成人发病IBD的风险（aHR 0.97，95% CI分别为0.87，1.07和1.08，95% CI分别为0.97，1.19）。将甲苯咪唑暴露限制在<5岁时，虽然与儿童发病IBD无关（aHR 0.98，95% CI 0.87，1.11），但成人发病IBD风险增加（aHR 1.17，95% CI 1.04，1.31）。UC（aHR 1.32，95% CI 1.12，1.55）而非CD（1.03，95% CI 0.87，1.22）导致风险增加。生命早期甲苯咪唑暴露与成人发病UC风险增加相关。这些研究结果表明，早期生活暴露在塑造IBD的风险在以后的生活的重要性。
According to the hygiene hypothesis, exposure to parasites may protect against inflammatory bowel disease (IBD). Our aim was to examine the risk of IBD with childhood exposure to mebendazole, a broad-spectrum antihelminthic agent. We conducted a population-based cohort study using prospectively collected historical data of all individuals born in Denmark between 1995 and 2018. We identified mebendazole exposure at age <18 years, as well as during early life (<5 years of age). We performed adjusted Cox proportional hazards regression analysis to determine the risk of IBD, ulcerative colitis (UC) and Crohn’s disease (CD) with mebendazole exposure after adjusting for potential confounders. Of 1,520,290 individuals in the cohort, 615,794 had childhood or adolescence mebendazole exposure. 1,555 and 1,499 individuals were subsequently diagnosed with pediatric- and adult-onset IBD, respectively. On multivariable analysis, mebendazole exposure at <18 years of age did not impact pediatric- or adult-onset IBD risk (aHR 0.97, 95% CI 0.87, 1.07 and 1.08, 95% CI 0.97, 1.19, respectively). On limiting mebendazole exposure to age <5 years, while there was no association with pediatric-onset IBD (aHR 0.98, 95% CI 0.87, 1.11), adult-onset IBD risk was increased (aHR 1.17, 95% CI 1.04, 1.31). This increase in risk was driven by UC (aHR 1.32, 95% CI 1.12, 1.55), but not CD (1.03, 95% CI 0.87,1.22). Early life mebendazole exposure is associated with increase in the risk of adult-onset UC. These findings suggest the importance of early life exposures in shaping the risk of IBD later in life.
登录
查看更多内容
影响因子：
4.3
作者：
Marques AH;O'Connor TG;Roth C;Susser E;Bjørke-Monsen AL
通讯作者：
Bjørke-Monsen AL
影响因子：
64.8
作者：
Stewart CJ;Ajami NJ;O'Brien JL;Hutchinson DS;Smith DP;Wong MC;Ross MC;Lloyd RE;Doddapaneni H;Metcalf GA;Muzny D;Gibbs RA;Vatanen T;Huttenhower C;Xavier RJ;Rewers M;Hagopian W;Toppari J;Ziegler AG;She JX;Akolkar B;Lernmark A;Hyoty H;Vehik K;Krischer JP;Petrosino JF
通讯作者：
Petrosino JF
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
1.9
作者：
Fonager, K;Sorensen, HT;Vyberg, M
通讯作者：
Vyberg, M
影响因子：
24.5
作者：
Lamb, Christopher Andrew;Kennedy, Nicholas A.;Hawthorne, A. Barney
通讯作者：
Hawthorne, A. Barney