The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders.
The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders.
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DOI：
10.3389/fnins.2013.00120
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发表时间：
2013
影响因子：
4.3
通讯作者：
Bjørke-Monsen AL
中科院分区：
文献类型：
--
作者：
Marques AH;O'Connor TG;Roth C;Susser E;Bjørke-Monsen AL
胎儿和儿童发育中的免疫系统和中枢神经系统对外源性和内源性信号都非常敏感。早期的免疫系统编程，导致可以持续整个生命过程的变化，已经提出，其他证据表明，早期发育的大脑中的免疫失调可能在神经发育障碍中发挥作用，如自闭症谱系障碍和精神分裂症。与胎龄和胎儿神经发育相关的免疫失调时机可能会影响所引发的反应。这可能会造成编程或漏洞的敏感窗口。这篇综述将探讨产妇产前和婴儿营养状况（从怀孕到幼儿期）以及产妇产前压力和焦虑对免疫功能早期编程的影响，以及这可能如何影响神经发育。我们将描述胎儿免疫系统的发育和母胎免疫相互作用，为理解营养和应激对免疫系统的影响提供更好的背景。最后，我们将讨论预防神经发育障碍的影响，重点是营养。虽然某些微量营养素补充剂已被证明可以降低神经发育障碍的风险并增强胎儿免疫发育，但我们不知道它们对免疫发育的影响是否有助于对神经发育障碍的预防作用。未来的研究需要阐明这种关系，这可能有助于更好地了解预防机制。将神经发育障碍和产前暴露的研究与神经和免疫系统的同时评估相结合，将揭示个体对神经发育障碍的脆弱性或恢复力的机制，并最终有助于初级预防和早期干预的发展。
The developing immune system and central nervous system in the fetus and child are extremely sensitive to both exogenous and endogenous signals. Early immune system programming, leading to changes that can persist over the life course, has been suggested, and other evidence suggests that immune dysregulation in the early developing brain may play a role in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. The timing of immune dysregulation with respect to gestational age and neurologic development of the fetus may shape the elicited response. This creates a possible sensitive window of programming or vulnerability. This review will explore the effects of maternal prenatal and infant nutritional status (from conception until early childhood) as well as maternal prenatal stress and anxiety on early programming of immune function, and how this might influence neurodevelopment. We will describe fetal immune system development and maternal-fetal immune interactions to provide a better context for understanding the influence of nutrition and stress on the immune system. Finally, we will discuss the implications for prevention of neurodevelopmental disorders, with a focus on nutrition. Although certain micronutrient supplements have shown to both reduce the risk of neurodevelopmental disorders and enhance fetal immune development, we do not know whether their impact on immune development contributes to the preventive effect on neurodevelopmental disorders. Future studies are needed to elucidate this relationship, which may contribute to a better understanding of preventative mechanisms. Integrating studies of neurodevelopmental disorders and prenatal exposures with the simultaneous evaluation of neural and immune systems will shed light on mechanisms that underlie individual vulnerability or resilience to neurodevelopmental disorders and ultimately contribute to the development of primary preventions and early interventions.
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影响因子：
64.5
作者：
BLACKMAN, M;YAGUE, J;MARRACK, P
通讯作者：
MARRACK, P
影响因子：
6.6
作者：
Brown, Alan S.;Patterson, Paul H.
通讯作者：
Patterson, Paul H.
影响因子：
8
作者：
Auestad, N;Scott, DT;Hall, RT
通讯作者：
Hall, RT
DOI：
10.1016/j.jaac.2013.02.010
发表时间：
2013-05-01
影响因子：
13.3
作者：
Braithwaite, Elizabeth C.;Ramchandani, Paul G.;Murphy, Susannah E.
通讯作者：
Murphy, Susannah E.
DOI：
10.1017/s1121189x00007946
发表时间：
2005-10-01
期刊：
EPIDEMIOLOGIA E PSICHIATRIA SOCIALE-AN INTERNATIONAL JOURNAL FOR EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
影响因子：
--
作者：
Bresnahan, M;Schaefer, CA;Susser, ES
通讯作者：
Susser, ES