Sodium channel Na v 1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome.
Sodium channel Na v 1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome.
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DOI：
10.1186/1471-2202-11-71
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发表时间：
2010-06-08
期刊：
影响因子：
2.4
通讯作者：
Anand P
中科院分区：
文献类型：
--
作者：
Beneng K;Renton T;Yilmaz Z;Yiangou Y;Anand P
电压门控钠通道Nav1.7参与伤害性感受器神经动作电位，已知在临床遗传性疾病中影响疼痛敏感性。研究牙髓炎疼痛(一种炎症状态)和灼口综合征(BMS)(被认为是一种神经病理性口面部疼痛障碍)中Nav1.7的水平。这项研究招募了两组患者。其中牙髓炎疼痛组5例，对照组12例；BMS组7例，对照组10例。BMS患者根据国际疼痛研究协会的标准进行诊断；收集疼痛病史，包括视觉模拟评分(VAS)。应用免疫组织化学和计算机图像分析技术检测牙髓炎组的牙髓组织标本和BMS组的舌活检组织中Nav1.7的表达水平。与对照组相比，疼痛牙髓标本中神经纤维中Nav1.7的视觉强度分数显著增加。图像分析显示，在疼痛牙髓组中，Nav1.7免疫反应%面积有增加的趋势，但这在统计学上没有显著意义。当表达为神经丝%面积的比率时，疼痛牙髓组的NAV1.7有明显的增加趋势。在舌活检组织的粘膜下层可见丰富的NAV1.7免疫反应纤维，而BMS组与对照组之间无显著差异。Nav1.7钠通道可能在炎症性牙痛中起重要作用。选择性Nav1.7通道阻滞剂的临床试验应该优先考虑牙髓疼痛，而不是BMS。
Voltage gated sodium channels Nav1.7 are involved in nociceptor nerve action potentials and are known to affect pain sensitivity in clinical genetic disorders. To study Nav1.7 levels in dental pulpitis pain, an inflammatory condition, and burning mouth syndrome (BMS), considered a neuropathic orofacial pain disorder. Two groups of patients were recruited for this study. One group consisted of patients with dental pulpitis pain (n = 5) and controls (n = 12), and the other patients with BMS (n = 7) and controls (n = 10). BMS patients were diagnosed according to the International Association for the Study of Pain criteria; a pain history was collected, including the visual analogue scale (VAS). Immunohistochemistry with visual intensity and computer image analysis were used to evaluate levels of Nav1.7 in dental pulp tissue samples from the dental pulpitis group, and tongue biopsies from the BMS group. There was a significantly increased visual intensity score for Nav1.7 in nerve fibres in the painful dental pulp specimens, compared to controls. Image analysis showed a trend for an increase of the Nav1.7 immunoreactive % area in the painful pulp group, but this was not statistically significant. When expressed as a ratio of the neurofilament % area, there was a strong trend for an increase of Nav1.7 in the painful pulp group. Nav1.7 immunoreactive fibres were seen in abundance in the sub-mucosal layer of tongue biopsies, with no significant difference between BMS and controls. Nav1.7 sodium channel may play a significant role in inflammatory dental pain. Clinical trials with selective Nav1.7 channel blockers should prioritise dental pulp pain rather than BMS.
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影响因子：
2.9
作者：
Renton T;Yiangou Y;Plumpton C;Tate S;Bountra C;Anand P
通讯作者：
Anand P
影响因子：
3
作者：
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通讯作者：
Boissonade, F. M.
影响因子：
2.6
作者：
Keh, Siew M.;Facer, Paul;Anand, Praveen
通讯作者：
Anand, Praveen
影响因子：
4.5
作者：
Brady, CM;Apostolidis, AN;Anand, P
通讯作者：
Anand, P
影响因子：
3.4
作者：
Suarez, Victor;Guntinas-Lichius, Orlando;Klimaschewski, Lars
通讯作者：
Klimaschewski, Lars