Noncoding RNAs and chronic inflammation: Micro-managing the fire within.

Noncoding RNAs and chronic inflammation: Micro-managing the fire within.
复制标题

DOI:
10.1002/bies.201500054
复制
发表时间:
2015-09
期刊:
影响因子:
4
通讯作者:
O'Connell, Ryan M.
O'Connell, Ryan M.
中科院分区:
生物学3区
文献类型:
--
作者:
Alexander, Margaret;O'Connell, Ryan M.

文献摘要

参考文献

被引文献

相似文献

炎症反应对于病原体的清除和受损组织的修复是必不可少的;然而,如果这些反应没有得到适当的控制,则可能发生慢性炎症。慢性炎症现在被认为是许多年龄相关疾病的促成因素,包括代谢紊乱、关节炎、神经变性和心血管疾病。由于慢性炎症与这些疾病之间的联系,了解这一过程背后的潜在机制至关重要。在这篇综述中,因素,有助于慢性炎症进行了讨论。此外,我们强调microRNA(miRNAs)和其他非编码RNA(ncRNA)在调节慢性炎症状态中的新兴作用,使其成为未来重要的诊断标志物和治疗靶点。Copyright Line:© 2015 The Authors BioEssays Published by Wiley‐VCH Verlag GmbH & Co. KGaA.
Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age‐associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets. Copyright Line: © 2015 The Authors BioEssays Published by Wiley‐VCH Verlag GmbH & Co. KGaA.
DOI: 10.1038/ni.2642
发表时间: 2013-08
期刊: Nature immunology
影响因子: 30.5
作者:
通讯作者: --
DOI: 10.1128/iai.66.5.2065-2071.1998
发表时间: 1998-05-01
影响因子: 3.1
作者:
Brown, CR;Reiner, SL
通讯作者: Reiner, SL
DOI: 10.1007/s11010-011-0727-3
发表时间: 2011-05-01
影响因子: 4.3
作者:
Balasubramanyam, M.;Aravind, S.;Mohan, V.
通讯作者: Mohan, V.
DOI: 10.1126/science.1240925
发表时间: 2013-08-16
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者: Fitzgerald KA
DOI: 10.1074/jbc.m112.426866
发表时间: 2013-12-06
影响因子: 4.8
作者:
Banerjee, Sami;Cui, Huachun;Liu, Gang
通讯作者: Liu, Gang