Synthesizing biomolecule-based Boolean logic gates.

Synthesizing biomolecule-based Boolean logic gates.
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DOI:
10.1021/sb3001112
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发表时间:
2013-02-15
影响因子:
4.7
通讯作者:
Inoue, Takanari
Inoue, Takanari
中科院分区:
生物学2区
文献类型:
--
作者:
Miyamoto, Takafumi;Razavi, Shiva;DeRose, Robert;Inoue, Takanari

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合成生物学领域最近一个引人入胜的研究领域是基于生物分子的计算机的创造。计算设备的主要组件包括算术逻辑单元、控制单元、存储器以及输入和输出设备。布尔逻辑门是这些部件运算机械的核心,因此,要使生物计算机成为现实,生物分子逻辑门成为必需品。事实上,随着更复杂的生物学工具的出现,基于核酸和蛋白质的逻辑系统都已经产生。这些设备在试管或活细胞的环境中发挥作用,并在给定一组输入的情况下产生高度特定的输出。在这篇综述中,我们讨论了已经合成的各种类型的生物分子逻辑门,特别是最近的进展,这些进展承诺增加逻辑门电路的复杂性,提高计算速度,以及潜在的临床应用。
One fascinating recent avenue of study in the field of synthetic biology is the creation of biomolecule-based computers. The main components of a computing device consist of an arithmetic logic unit, the control unit, memory, and the input and output devices. Boolean logic gates are at the core of the operational machinery of these parts, hence to make biocomputers a reality, biomolecular logic gates become a necessity. Indeed, with the advent of more sophisticated biological tools, both nucleic acid- and protein-based logic systems have been generated. These devices function in the context of either test tubes or living cells and yield highly specific outputs given a set of inputs. In this review, we discuss various types of biomolecular logic gates that have been synthesized, with particular emphasis on recent developments that promise increased complexity of logic gate circuitry, improved computational speed, and potential clinical applications.
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